Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - fungal/metazoan cullin-1

PR:000000092 - http://purl.obolibrary.org/obo/PR_000000092

Protein Forms

Complex

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000000092

PRO name

fungal/metazoan cullin-1

Synonyms

PRO-Short-label:	EXACT:	CUL1
Other:	EXACT:	CUL-1

Definition

"A cullin that is a translation product of the human CUL1 gene or a 1:1 ortholog thereof in fungi or metazoa." [PRO:CNA]

PRO Category

gene

Parent

PR:000000013 cullin
PR:000036194 eukaryotic protein

Taxon

NCBITaxon:33154 Opisthokonta

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	7
Sequence	1	Organism-Sequence	2
Modification	2	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Protein Forms

Switch to Extended View

Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000092 fungal/metazoan cullin-1

CUL1

Yes

organism-gene

PR:O13790 cullin-1 (Schizosaccharomyces pombe 972h-)

Spom972h-CUL1

organism-gene

PR:O60999 cullin-1 (Dictyostelium discoideum)

Dicty-CUL1

organism-gene

PR:Q12018 cell division control protein 53 (yeast)

yCUL1

organism-gene

PR:Q13616 cullin-1 (human)

hCUL1

Yes

organism-sequence

PR:Q13616-1 cullin-1 isoform 1 (human)

hCUL1/iso:1

Yes

organism-modification

PR:000036454 cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1

Yes

organism-modification

PR:000064861 cullin-1 neddylated 1 (human)

hCUL1/Nedd:1

organism-modification

PR:000071994 cullin-1 methylated 1 (human)

hCUL1/Me:1

organism-modification

PR:000075174 cullin-1 cysteinylated 1 (human)

hCUL1/Cyst:1

organism-gene

PR:Q17389 cullin-1 (worm)

CUL1 (worm)

organism-gene

PR:Q24311 cullin homolog 1 (fruit fly)

fly-CUL1

organism-gene

PR:Q9WTX6 cullin-1 (mouse)

mCUL1

organism-sequence

PR:Q9WTX6-1 cullin-1 isoform 1 (mouse)

mCUL1/iso:1

sequence

PR:000000267 fungal/metazoan cullin-1 isoform 1

CUL1/iso:1

organism-sequence

PR:Q13616-1 cullin-1 isoform 1 (human)

hCUL1/iso:1

Yes

organism-modification

PR:000036454 cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1

Yes

organism-sequence

PR:Q9WTX6-1 cullin-1 isoform 1 (mouse)

mCUL1/iso:1

modification

PR:000000427 fungal/metazoan cullin-1 isoform 1 neddylated form

CUL1/iso:1/NeddLys+

modification

PR:000000542 fungal/metazoan cullin-1 isoform 1 neddylated 1

CUL1/iso:1/Nedd:1

organism-modification

PR:000036454 cullin-1 isoform 1 neddylated 1 (human)

hCUL1/iso:1/Nedd:1

Yes

Back to top

CUL1 forms found in complexes

CUL1 Component	Complexes
PR:Q13616 hCUL1	PR:000026771 SCF beta-TrCP complex (human)
	PR:000026772 SCF(Skp2) complex (human)
	PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)

Back to top

Functional Annotation (PRO-centric view)

Switch to GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000092 CUL1	acts_upstream_of_or_within	GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PANTHER:PTHR11932
PR:000000092 CUL1	located_in	GO:0019005 SCF ubiquitin ligase complex	PANTHER:PTHR11932
PR:000036454 hCUL1/iso:1/Nedd:1 UniProtKB:Q13616-1, Lys-720, MOD:01150	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:8681378
		GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:10713156; PMID:10921923
		GO:0051726 regulation of cell cycle	PMID:8681378
		GO:0097193 intrinsic apoptotic signaling pathway	PMID:8681378
	located_in	GO:0019005 SCF ubiquitin ligase complex	PMID:10713156; PMID:10921923; PMID:17098746
PR:Q13616-1 hCUL1/iso:1	enables	GO:0005515 protein binding with PR:P62877-1	PMID:12504026; PMID:15537541
	enables	GO:0005515 protein binding with PR:Q86VP6-1	PMID:12504026; PMID:15537541
	located_in	NOT GO:0019005 SCF ubiquitin ligase complex	PMID:10713156; PMID:10921923; PMID:12504026