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Protein Ontology report - interleukin-1 receptor-associated kinase 3
PR:000001784 - http://purl.obolibrary.org/obo/PR_000001784
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001784   
  PRO nameinterleukin-1 receptor-associated kinase 3 
  Synonyms
PRO-Short-label: EXACT:IRAK3
Other: EXACT:IL-1 receptor-associated kinase M | inactive IL-1 receptor-associated kinase 3 | IRAK-3 | IRAK-M
  Definition"An interleukin-1 receptor-associated kinase IRAK1/3 that is a translation product of the human IRAK3 gene or a 1:1 ortholog thereof." [PMID:12150927, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000001781 interleukin-1 receptor-associated kinase IRAK1/3
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2044
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000001784 interleukin-1 receptor-associated kinase 3
IRAK3

organism-gene


PR:G5ECP4 pelle-like serine/threonine-protein kinase pik-1 (worm)
IRAK3 (worm)

organism-sequence


PR:G5ECP4-1 pelle-like serine/threonine-protein kinase pik-1 isoform a (worm)
IRAK3/iso:a (worm)

organism-sequence


PR:G5ECP4-2 pelle-like serine/threonine-protein kinase pik-1 isoform b (worm)
IRAK3/iso:b (worm)

organism-gene


PR:Q8K4B2 interleukin-1 receptor-associated kinase 3 (mouse)
mIRAK3
Yes
Yes
organism-gene


PR:Q9Y616 interleukin-1 receptor-associated kinase 3 (human)
hIRAK3

organism-sequence


PR:Q9Y616-1 interleukin-1 receptor-associated kinase 3 isoform 1 (human)
hIRAK3/iso:1
Yes
organism-sequence


PR:Q9Y616-2 interleukin-1 receptor-associated kinase 3 isoform h2 (human)
hIRAK3/iso:h2

organism-modification


PR:000073219 interleukin-1 receptor-associated kinase 3 phosphorylated 1 (human)
hIRAK3/Phos:1

sequence


PR:000027241 interleukin-1 receptor-associated kinase 3 isoform 1
IRAK3/iso:1

organism-sequence


PR:Q9Y616-1 interleukin-1 receptor-associated kinase 3 isoform 1 (human)
hIRAK3/iso:1
Yes
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IRAK3 forms found in complexes   

IRAK3 Component
 Complexes
PR:Q8K4B2 mIRAK3 PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8K4B2 mIRAK3 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:12150927
PR:Q9Y616-1 hIRAK3/iso:1 acts_upstream_of_or_withinGO:0034122 negative regulation of toll-like receptor signaling pathway PMID:10383454
enablesGO:0005515 protein binding with PR:Q99836 hMYD88 PMID:10383454