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Protein Ontology report - mothers against decapentaplegic homolog 4 (human)
PR:Q13485 - http://purl.obolibrary.org/obo/PR_Q13485
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:Q13485   
  PRO namemothers against decapentaplegic homolog 4 (human) 
  Synonyms
PRO-Short-label: EXACT:hSMAD4
Gene-based: RELATED:DPC4 | MADH4 | SMAD4
Other: EXACT:deletion target in pancreatic carcinoma 4 (human) | MAD homolog 4 (human) | mothers against DPP homolog 4 (human) | SMAD 4 (human) | SMAD family member 4 (human) | Smad4 (human)
  Definition"A smad4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13485
  PRO Categoryorganism-gene  
  ParentPR:000000128 smad4
PR:000029067 Homo sapiens protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 89                                        
         Modification0                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:Q13485
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Protein Forms   

Category  

PRO Form Name

Comp. In Complex?

Ann. Has Annotation?
organism-gene



PR:Q13485 mothers against decapentaplegic homolog 4 (human), hSMAD4


Yes
organism-sequence



PR:000000367 smad4 sequence variant E330G (human), hSMAD4/var:E330G

Yes

organism-sequence



PR:000000368 smad4 sequence variant G352R (human), hSMAD4/var:G352R

Yes

organism-sequence



PR:000000369 smad4 sequence variant R361C (human), hSMAD4/var:R361C

Yes

organism-sequence



PR:000000370 smad4 sequence variant G386D (human), hSMAD4/var:G386D

Yes

organism-sequence



PR:000000371 smad4 sequence variant D493H (human), hSMAD4/var:D493H

Yes

organism-sequence



PR:000060297 mothers against decapentaplegic homolog 4 sequence variant E538* (human), hSMAD4/var:E538*


organism-sequence



PR:000060358 mothers against decapentaplegic homolog 4 sequence variant D351G (human), hSMAD4/var:D351G


organism-sequence



PR:000060432 mothers against decapentaplegic homolog 4 sequence variant G30* (human), hSMAD4/var:G30*


organism-sequence



PR:000060505 mothers against decapentaplegic homolog 4 sequence variant R445* (human), hSMAD4/var:R445*


organism-sequence



PR:000060581 mothers against decapentaplegic homolog 4 sequence variant E390* (human), hSMAD4/var:E390*


organism-sequence



PR:000060584 mothers against decapentaplegic homolog 4 sequence variant G358* (human), hSMAD4/var:G358*


organism-sequence



PR:000060627 mothers against decapentaplegic homolog 4 sequence variant Q410* (human), hSMAD4/var:Q410*


organism-sequence



PR:000060690 mothers against decapentaplegic homolog 4 sequence variant D351H (human), hSMAD4/var:D351H


organism-sequence



PR:000060699 mothers against decapentaplegic homolog 4 sequence variant E526* (human), hSMAD4/var:E526*


organism-sequence



PR:000060742 mothers against decapentaplegic homolog 4 sequence variant Q83* (human), hSMAD4/var:Q83*


organism-sequence



PR:000060841 mothers against decapentaplegic homolog 4 sequence variant Y276* (human), hSMAD4/var:Y276*


organism-sequence



PR:000060874 mothers against decapentaplegic homolog 4 sequence variant G473* (human), hSMAD4/var:G473*


organism-sequence



PR:000060913 mothers against decapentaplegic homolog 4 sequence variant G477* (human), hSMAD4/var:G477*


organism-sequence



PR:000060944 mothers against decapentaplegic homolog 4 sequence variant E49* (human), hSMAD4/var:E49*


organism-sequence



PR:000060985 mothers against decapentaplegic homolog 4 sequence variant W398* (human), hSMAD4/var:W398*


organism-sequence



PR:000060992 mothers against decapentaplegic homolog 4 sequence variant Q183* (human), hSMAD4/var:Q183*


organism-sequence



PR:000061015 mothers against decapentaplegic homolog 4 sequence variant Y95* (human), hSMAD4/var:Y95*


organism-sequence



PR:000061059 mothers against decapentaplegic homolog 4 sequence variant Q116* (human), hSMAD4/var:Q116*


organism-sequence



PR:000061241 mothers against decapentaplegic homolog 4 sequence variant W302* (human), hSMAD4/var:W302*


organism-sequence



PR:000061304 mothers against decapentaplegic homolog 4 sequence variant E330* (human), hSMAD4/var:E330*


organism-sequence



PR:000061339 mothers against decapentaplegic homolog 4 sequence variant C443* (human), hSMAD4/var:C443*


organism-sequence



PR:000061457 mothers against decapentaplegic homolog 4 sequence variant Q249* (human), hSMAD4/var:Q249*


organism-sequence



PR:000061581 mothers against decapentaplegic homolog 4 sequence variant E108* (human), hSMAD4/var:E108*


organism-sequence



PR:000061625 mothers against decapentaplegic homolog 4 sequence variant Y412* (human), hSMAD4/var:Y412*


organism-sequence



PR:000061684 mothers against decapentaplegic homolog 4 sequence variant W524* (human), hSMAD4/var:W524*


organism-sequence



PR:000061708 mothers against decapentaplegic homolog 4 sequence variant K428R (human), hSMAD4/var:K428R


organism-sequence



PR:000061756 mothers against decapentaplegic homolog 4 sequence variant E175* (human), hSMAD4/var:E175*


organism-sequence



PR:000061768 mothers against decapentaplegic homolog 4 sequence variant Q516* (human), hSMAD4/var:Q516*


organism-sequence



PR:000061774 mothers against decapentaplegic homolog 4 sequence variant L440* (human), hSMAD4/var:L440*


organism-sequence



PR:000061833 mothers against decapentaplegic homolog 4 sequence variant Q224* (human), hSMAD4/var:Q224*


organism-sequence



PR:000061868 mothers against decapentaplegic homolog 4 sequence variant Q256* (human), hSMAD4/var:Q256*


organism-sequence



PR:000061967 mothers against decapentaplegic homolog 4 sequence variant A406T (human), hSMAD4/var:A406T


organism-sequence



PR:000061978 mothers against decapentaplegic homolog 4 sequence variant W268* (human), hSMAD4/var:W268*


organism-sequence



PR:000062067 mothers against decapentaplegic homolog 4 sequence variant P356R (human), hSMAD4/var:P356R


organism-sequence



PR:000062090 mothers against decapentaplegic homolog 4 sequence variant Q248* (human), hSMAD4/var:Q248*


organism-sequence



PR:000062129 mothers against decapentaplegic homolog 4 sequence variant Y513* (human), hSMAD4/var:Y513*


organism-sequence



PR:000062175 mothers against decapentaplegic homolog 4 sequence variant G510* (human), hSMAD4/var:G510*


organism-sequence



PR:000062259 mothers against decapentaplegic homolog 4 sequence variant G352* (human), hSMAD4/var:G352*


organism-sequence



PR:000062302 mothers against decapentaplegic homolog 4 sequence variant R361G (human), hSMAD4/var:R361G


organism-sequence



PR:000062369 mothers against decapentaplegic homolog 4 sequence variant E307* (human), hSMAD4/var:E307*


organism-sequence



PR:000062486 mothers against decapentaplegic homolog 4 sequence variant D351Y (human), hSMAD4/var:D351Y


organism-sequence



PR:000062687 mothers against decapentaplegic homolog 4 sequence variant W509* (human), hSMAD4/var:W509*


organism-sequence



PR:000062700 mothers against decapentaplegic homolog 4 sequence variant K428T (human), hSMAD4/var:K428T


organism-sequence



PR:000062729 mothers against decapentaplegic homolog 4 sequence variant Q366* (human), hSMAD4/var:Q366*


organism-sequence



PR:000062770 mothers against decapentaplegic homolog 4 sequence variant R361S (human), hSMAD4/var:R361S


organism-sequence



PR:000062793 mothers against decapentaplegic homolog 4 sequence variant Y195* (human), hSMAD4/var:Y195*


organism-sequence



PR:000062878 mothers against decapentaplegic homolog 4 sequence variant Y328* (human), hSMAD4/var:Y328*


organism-sequence



PR:000062888 mothers against decapentaplegic homolog 4 sequence variant Q289* (human), hSMAD4/var:Q289*


organism-sequence



PR:000062894 mothers against decapentaplegic homolog 4 sequence variant S154* (human), hSMAD4/var:S154*


organism-sequence



PR:000062923 mothers against decapentaplegic homolog 4 sequence variant W101* (human), hSMAD4/var:W101*


organism-sequence



PR:000062931 mothers against decapentaplegic homolog 4 sequence variant Q534* (human), hSMAD4/var:Q534*


organism-sequence



PR:000062943 mothers against decapentaplegic homolog 4 sequence variant L146* (human), hSMAD4/var:L146*


organism-sequence



PR:000062969 mothers against decapentaplegic homolog 4 sequence variant Q455* (human), hSMAD4/var:Q455*


organism-sequence



PR:000063050 mothers against decapentaplegic homolog 4 sequence variant K122* (human), hSMAD4/var:K122*


organism-sequence



PR:000063052 mothers against decapentaplegic homolog 4 sequence variant R515T (human), hSMAD4/var:R515T


organism-sequence



PR:000063094 mothers against decapentaplegic homolog 4 sequence variant P356L (human), hSMAD4/var:P356L


organism-sequence



PR:000063098 mothers against decapentaplegic homolog 4 sequence variant E417* (human), hSMAD4/var:E417*


organism-sequence



PR:000063207 mothers against decapentaplegic homolog 4 sequence variant Q311* (human), hSMAD4/var:Q311*


organism-sequence



PR:000063208 mothers against decapentaplegic homolog 4 sequence variant Y260* (human), hSMAD4/var:Y260*


organism-sequence



PR:000063251 mothers against decapentaplegic homolog 4 sequence variant Q239* (human), hSMAD4/var:Q239*


organism-sequence



PR:000063265 mothers against decapentaplegic homolog 4 sequence variant S242* (human), hSMAD4/var:S242*


organism-sequence



PR:000063355 mothers against decapentaplegic homolog 4 sequence variant S138* (human), hSMAD4/var:S138*


organism-sequence



PR:000063397 mothers against decapentaplegic homolog 4 sequence variant Q442* (human), hSMAD4/var:Q442*


organism-sequence



PR:000063419 mothers against decapentaplegic homolog 4 sequence variant R515* (human), hSMAD4/var:R515*


organism-sequence



PR:000063609 mothers against decapentaplegic homolog 4 sequence variant G168* (human), hSMAD4/var:G168*


organism-sequence



PR:000063714 mothers against decapentaplegic homolog 4 sequence variant E520* (human), hSMAD4/var:E520*


organism-sequence



PR:000063741 mothers against decapentaplegic homolog 4 sequence variant E205* (human), hSMAD4/var:E205*


organism-sequence



PR:000063751 mothers against decapentaplegic homolog 4 sequence variant E53* (human), hSMAD4/var:E53*


organism-sequence



PR:000063757 mothers against decapentaplegic homolog 4 sequence variant R135* (human), hSMAD4/var:R135*


organism-sequence



PR:000063792 mothers against decapentaplegic homolog 4 sequence variant Q334* (human), hSMAD4/var:Q334*


organism-sequence



PR:000063853 mothers against decapentaplegic homolog 4 sequence variant Y322* (human), hSMAD4/var:Y322*


organism-sequence



PR:000063915 mothers against decapentaplegic homolog 4 sequence variant Q245* (human), hSMAD4/var:Q245*


organism-sequence



PR:000063918 mothers against decapentaplegic homolog 4 sequence variant S144* (human), hSMAD4/var:S144*


organism-sequence



PR:000064002 mothers against decapentaplegic homolog 4 sequence variant Q250* (human), hSMAD4/var:Q250*


organism-sequence



PR:000064188 mothers against decapentaplegic homolog 4 sequence variant S178* (human), hSMAD4/var:S178*


organism-sequence



PR:000064193 mothers against decapentaplegic homolog 4 sequence variant E33* (human), hSMAD4/var:E33*


organism-sequence



PR:000064298 mothers against decapentaplegic homolog 4 sequence variant S171* (human), hSMAD4/var:S171*


organism-sequence



PR:000064338 mothers against decapentaplegic homolog 4 sequence variant Y430* (human), hSMAD4/var:Y430*


organism-sequence



PR:000064356 mothers against decapentaplegic homolog 4 sequence variant S343* (human), hSMAD4/var:S343*


organism-sequence



PR:000064413 mothers against decapentaplegic homolog 4 sequence variant Q448* (human), hSMAD4/var:Q448*


organism-sequence



PR:000064414 mothers against decapentaplegic homolog 4 sequence variant L172* (human), hSMAD4/var:L172*


organism-sequence



PR:000064437 mothers against decapentaplegic homolog 4 sequence variant E321* (human), hSMAD4/var:E321*


organism-sequence



PR:000064488 mothers against decapentaplegic homolog 4 sequence variant R361H (human), hSMAD4/var:R361H


organism-sequence



PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human), hSMAD4/iso:1

Yes

Yes
organism-modification



PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1


organism-modification



PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2

Yes

organism-modification



PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1

Yes

organism-modification



PR:000045915 mothers against decapentaplegic homolog 4 phosphorylated 1 (human), hSMAD4/Phos:1


organism-modification



PR:000049288 mothers against decapentaplegic homolog 4 ADP-ribosylated form (human), hSMAD4/ADPribRes+


organism-modification



PR:000064798 mothers against decapentaplegic homolog 4 ubiquitinated form (human), hSMAD4/UbiqLys+


organism-modification



PR:000067581 mothers against decapentaplegic homolog 4 methylated 1 (human), hSMAD4/Me:1


organism-modification



PR:000074844 mothers against decapentaplegic homolog 4 methylated 2 (human), hSMAD4/Me:2


organism-modification



PR:000075597 mothers against decapentaplegic homolog 4 deaminated 1 (human), hSMAD4/Deam:1


organism-modification



PR:000083975 mothers against decapentaplegic homolog 4 methylated 3 (human), hSMAD4/Me:3


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hSMAD4 forms found in complexes   

hSMAD4 Component
Complexes
PR:Q13485 hSMAD4 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:Q13485ZDASHZ1 hSMAD4/iso:1 PR:000025940^P000025946^P000025947^P000025951^P000025952
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000367 hSMAD4/var:E330G associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000368 hSMAD4/var:G352R associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
DO:4905 pancreatic carcinoma PMID:12417513
PR:000000369 hSMAD4/var:R361C associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:9811934
PR:000000370 hSMAD4/var:G386D associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:15031030
PR:000000371 hSMAD4/var:D493H associated_with_disease_progressionDO:4905 pancreatic carcinoma PMID:8553070
PR:000025958 hSMAD4/iso:1/MonoUbiq:2 acts_upstream_of_or_withinGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
enablesNOT GO:0046332 SMAD binding PMID:19135894
PR:000036483 hSMAD4/iso:1/Phos:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
enablesincreased GO:0003700 DNA-binding transcription factor activity PMID:12801888
located_inGO:0005634 nucleus PMID:12801888
PR:Q13485-1 hSMAD4/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805; PMID:8774881
GO:0030509 BMP signaling pathway PMID:14633973
GO:0060395 SMAD protein signal transduction PMID:10980615; PMID:15350224; PMID:9346966
enablesGO:0003700 DNA-binding transcription factor activity PMID:10823886
GO:0003712 transcription coregulator activity PMID:10980615
located_inGO:0005634 nucleus PMID:10980615; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
GO:0005737 cytoplasm PMID:15280432