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Protein Ontology Report - p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex

PR:000037319 - http://purl.obolibrary.org/obo/PR_000037319
Ontology Information
PRO ID PR:000037319 Show OBO stanza / PAF
PRO name p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
Synonyms
RELATED: activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-IKK epsilon
Definition A protein complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, and phosphorylated IKK epsilon. [PMID:14530355, PMID:16281057, PMID:16306936, PMID:19656901, Reactome:R-HSA-936970]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037320 PR:Q13114 TNF receptor-associated factor 3 (human) hTRAF3 A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000028691 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human) hIKBKE/Phos:1 An inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 in human. Example: UniProtKB:Q14164-1, Ser-172, MOD:00046. [PMID:10421793, PRO:CNA, Reactome:R-HSA-450278] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-905. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human) hTRAF3/K63polyUbiq+ A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772. [Reactome:R-HSA-936402] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037320
p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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