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Protein Ontology Report - hTRAF3

PR:Q13114 - http://purl.obolibrary.org/obo/PR_Q13114
This page represents a class of proteins encompassing all the protein products of the TRAF3 gene in human.
Ontology Information
PRO ID PR:Q13114 Show OBO stanza / PAF
PRO name TNF receptor-associated factor 3 (human)
Synonyms
PRO-short-label: EXACT: hTRAF3
Gene-based: RELATED: CAP1 | CRAF1 | TRAF3
Other: EXACT: CAP-1 (human) | CD40 receptor-associated factor 1 (human) | CD40-binding protein (human) | CD40BP (human) | LAP1 (human) | LMP1-associated protein 1 (human) | RING-type E3 ubiquitin transferase TRAF3 (human)
Definition A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA]
PRO Category organism-gene
Parent PR:000002289 TNF receptor-associated factor 3
Gene Template HGNC:12033 TRAF3
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 2
organism-modification 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hTRAF3 forms found in complexes
hTRAF3 Component Complexes
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:000036032 hTRAF3/K63polyUbiq+ PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13114 hTRAF3 PR:000037310 traf3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:Q13114 hTRAF3 PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
PR:Q13114 hTRAF3 PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037356
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000036124
p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037358
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036041
K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_124855
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036034
IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036123
p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_26959
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036036
IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000037315
K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036030
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
PR:000036022
traf3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004842 ubiquitin-protein transferase activity Reactome:REACT_124037
located_in GO:0010008 endosome membrane Reactome:REACT_124037
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_124037
PR:000037310
traf3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000037322
p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
PR:000037320
p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
PR:000036038
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)
capable_of GO:0004674 protein serine/threonine kinase activity Reactome:REACT_27000
located_in GO:0010008 endosome membrane Reactome:REACT_27000
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
Molecular Function GO Term Protein Forms & Complexes Evidence
GO:0004674 protein serine/threonine kinase activity PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
GO:0004842 ubiquitin-protein transferase activity PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_6809
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_6809
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124037
PR:000036030 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036034 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036036 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036038 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_27000
PR:000036041 K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_124855
PR:000036123 p-tbk1:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000036124 p-IKKE:K63-poly-Ub-TRAF3:ticam1:ticam2:activated TLR4 complex complex (human)

Reactome:REACT_26959
PR:000037310 traf3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037315 K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037320 p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037322 p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037358 IRF3:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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