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Protein Ontology Report - IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

PR:000037354 - http://purl.obolibrary.org/obo/PR_000037354
Ontology Information
PRO ID PR:000037354 Show OBO stanza / PAF
PRO name IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
Synonyms
Other: RELATED: activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKKE:IRF3 (human)
Definition An IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex whose components are encoded in the genome of human. [PMID:14517278, PMID:14739303, PMID:16281057, PRO:VS, Reactome:REACT_27000]
Comment Requested by=TLR.
PRO Category organism-complex
Parent PR:000037353 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037354 PR:Q13114 TNF receptor-associated factor 3 (human) hTRAF3 A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA] 2
PR:000028702 interferon regulatory factor 3 unmodified form (human) hIRF3/UnMod An interferon regulatory factor 3 unmodified form in human. [PRO:CNA] 2
PR:000028695 serine/threonine-protein kinase TBK1 phosphorylated 1 (human) hTBK1/Phos:1 A serine/threonine-protein kinase TBK1 phosphorylated 1 in human. UniProtKB:Q9UHD2, Ser-172, MOD:00046. [PRO:CNA, Reactome:R-HSA-450290] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human) hTRAF3/K63polyUbiq+ A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772. [Reactome:R-HSA-936402] 2
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037354
IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
located_in GO:0010008 endosome membrane Reactome:REACT_6783
participates_in GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
participates_in GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0002756 MyD88-independent toll-like receptor signaling pathway PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
GO:0034138 toll-like receptor 3 signaling pathway PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037354 IRF3:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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