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Protein Ontology Report - Rho-associated protein kinase

PR:000000024 -
Ontology Information
PRO ID PR:000000024 Show OBO stanza / PAF
PRO name Rho-associated protein kinase
Definition A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an N-terminal Protein kinase domain (Pfam:PF00069), a Rho Binding domain (Pfam:PF08912), and a PH domain (Pfam:PF00169) and a Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130) at the C-terminus. Rho-associated protein kinases are mediators of many cellular processes by being effectors of the small GTP-binding protein Rho. [PRO:CNA]
PRO Category family
Parent PR:000000001 protein
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
Rho-associated protein kinase
acts_upstream_of_or_within GO:0007266 Rho protein signal transduction PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
acts_upstream_of_or_within GO:0006468 protein phosphorylation PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
enables GO:0004672 protein kinase activity PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568
enables GO:0004674 protein serine/threonine kinase activity PANTHER:PTHR22988:SF3, PIRSF:PIRSF037568