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Protein Ontology Report - bone morphogenetic protein

PR:000000034 -
Ontology Information
PRO ID PR:000000034 Show OBO stanza / PAF
PRO name bone morphogenetic protein
Definition A TGF-beta-like cystine-knot cytokine that is related to the transforming growth factor-beta, anti-Muellerian hormone, and activin/inhibin protein families, which are all involved in the regulation of cell growth and differentiation. These are produced as dimeric precursors and undergo post-translational processing for activation, requiring cleavage to release bioactive the C-terminal peptide. BMP is involved in body patterning and morphogenesis. BMP signals are transmitted through specific type 2 and type 1 receptors. [PIRSF:PIRSF037272]
PRO Category family
Parent PR:000000008 TGF-beta-like cystine-knot cytokine
Term Hierarchy Visualization DAG     OLS     Cytoscape

Functional Annotation
PRO Term GO Annotation Evidence
bone morphogenetic protein
enables GO:0042803 protein homodimerization activity PIRSF:PIRSF037272
enables GO:0005102 signaling receptor binding PIRSF:PIRSF037272
enables GO:0005125 cytokine activity PIRSF:PIRSF037272
enables GO:0008083 growth factor activity PIRSF:PIRSF037272