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Protein Ontology Report - BMPR2

PR:000000037 - http://purl.obolibrary.org/obo/PR_000000037
Ontology Information
PRO ID PR:000000037 Show OBO stanza / PAF
PRO name BMP receptor type-2
Synonyms
PRO-short-label: EXACT: BMPR2
Gene-based: RELATED: PPH1
Other: EXACT: BMP type II receptor | BMP type-2 receptor | BMPR-2 | BMPR-II | BRK-3 | bone morphogenetic protein receptor type II
Definition A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human BMPR2 gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. [PRO:CNA]
PRO Category gene
Parent PR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 2
sequence 1 organism-sequence 17
modification 0 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000000154
hBMPR2/var:N519K
Asn-519, CHEBI:29967 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension UniProtKB_VAR:VAR_013683
PR:000000155
hBMPR2/var:C117Y
Cys-117, CHEBI:46858 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11015450
PR:O35607-1
mBMPR2/iso:1
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PMID:12117821
located_in GO:0009986 cell surface PMID:12117821
PR:000000149
hBMPR2/var:C60Y
Cys-60, CHEBI:46858 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11015450
PR:000000037
BMPR2
acts_upstream_of_or_within GO:0030509 BMP signaling pathway PIRSF:PIRSF500434
PR:000000152
hBMPR2/var:R491W
Arg-491, CHEBI:29954 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10903931
PR:000000153
hBMPR2/var:K512T
Lys-512, CHEBI:30013 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378
PR:000000150
hBMPR2/var:D485G
Asp-485, CHEBI:29947 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10973254
PR:000000151
hBMPR2/var:R491Q
Arg-491, CHEBI:30011 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10903931
PR:000000156
hBMPR2/var:C118W
Cys-118, CHEBI:29954 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10973254
PR:000000157
hBMPR2/var:C123R
Cys-123, CHEBI:29952 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378
PR:000000161
hBMPR2/var:C420R
Cys-420, CHEBI:29952 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378
PR:000000160
hBMPR2/var:C347Y
Cys-347, CHEBI:46858 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10973254
PR:Q13873-1
hBMPR2/iso:1
acts_upstream_of_or_within GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:7644468
enables GO:0005515 protein binding with PR:P18075 hBMP7 PMID:7791754
enables GO:0005515 protein binding with PR:P12643 hBMP2 PMID:7791754
located_in GO:0009986 cell surface PMID:10712517
located_in GO:0005886 plasma membrane PMID:7791754
part_of GO:0043235 receptor complex PMID:7791754
PR:000000158
hBMPR2/var:C123S
Cys-123, CHEBI:29999 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378
PR:000000159
hBMPR2/var:E224D
Glu-224, CHEBI:29958 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378
PR:000000162
hBMPR2/var:C483R
Cys-483, CHEBI:29952 		associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11015450, PMID:12358323
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0009986 cell surface PR:O35607-1 mBMPR2/iso:1

PMID:12117821
PR:Q13873-1 hBMPR2/iso:1

PMID:10712517
GO:0005886 plasma membrane PR:Q13873-1 hBMPR2/iso:1

PMID:7791754

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