PRO Entry Report - PR:000000063

Protein Ontology Report - hTGFBR2/var:V447A

PR:000000063 - http://purl.obolibrary.org/obo/PR_000000063

Protein Forms Annotations

Ontology Information

PRO ID

PR:000000063 Show OBO stanza / PAF / GPI

PRO name

TGF-beta receptor type-2 sequence variant V447A (human)

Synonyms

PRO-short-label:	EXACT:	hTGFBR2/var:V447A
PRO-proteoform-std:	NARROW:	UniProtKB:P37173-1, Val-447, CHEBI:46217
Other:	EXACT:	TGF-beta receptor type-2 sequence variant 7 (human)

Definition

A TGF-beta receptor type-2 (human) that has an Ala residue at the position equivalent to Val-447 of the amino acid sequence represented by UniProtKB:P37173-1. Example: UniProtKB:P37173-1, Val-447, CHEBI:46217. [PMID:11212236, PRO:CNA, PRO:DAN]

Comment

Note: This form is involved in breast tumors.

PRO Category

organism-sequence

Parent

PR:P37173 TGF-beta receptor type-2 (human)

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Related Cross References
DB identifiers	UniProtKB_VAR:VAR_022357

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000063 hTGFBR2/var:V447A Val-447, CHEBI:46217	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11212236
	enables	GO:0005026 transforming growth factor beta receptor activity, type II decreased relative to PR:000000409 TGFBR2/iso:RII-1/SigPep-	PMID:11212236
	located_in	GO:0016020 membrane	PMID:11212236

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0016020 membrane	PR:000000063 hTGFBR2/var:V447A Val-447, CHEBI:46217	PMID:11212236

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