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Protein Ontology Report - ACVR2B

PR:000000071 - http://purl.obolibrary.org/obo/PR_000000071
Ontology Information
PRO ID PR:000000071 Show OBO stanza / PAF
PRO name activin receptor type-2B
Synonyms
PRO-short-label: EXACT: ACVR2B
Other: EXACT: ACTR-IIB | activin receptor type IIB
Definition A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 4
sequence 5 organism-sequence 9
modification 2 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:P27040-1
mACVR2B/iso:ActR-IIB1
located_in GO:0005886 plasma membrane PMID:1310075
part_of GO:0048179 activin receptor complex PMID:1310075
PR:000000071
ACVR2B
acts_upstream_of_or_within GO:0032924 activin receptor signaling pathway PIRSF:PIRSF500456
enables GO:0048185 activin binding PIRSF:PIRSF500456
PR:000000215
hACVR2B/var:V494I
Val-494, CHEBI:30009 		associated_with_disease_progression DOID:0050545 visceral heterotaxy PMID:9916847
PR:000000214
hACVR2B/var:R40H
Arg-40, CHEBI:29979 		associated_with_disease_progression DOID:0050545 visceral heterotaxy PMID:9916847
PR:P27040-4
mACVR2B/iso:ActR-IIB4
located_in GO:0005886 plasma membrane PMID:1310075
part_of GO:0048179 activin receptor complex PMID:1310075
PR:P27040-3
mACVR2B/iso:ActR-IIB3
located_in GO:0005886 plasma membrane PMID:1310075
part_of GO:0048179 activin receptor complex PMID:1310075
PR:000036443
hACVR2B/iso:ActR-IIB2/NGlycoPhos:1
enables GO:0016362 activin receptor activity, type II PMID:8622651
enables GO:0005515 protein binding with PR:Q9UNH7 hSNX6 PMID:11279102, PMID:9872992
enables GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8622651
located_in GO:0005886 plasma membrane PMID:8161782
part_of GO:0048179 activin receptor complex PMID:8622651
PR:000036442
mACVR2B/iso:ActR-IIB2/NGlycoPhos:1
acts_upstream_of_or_within GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:8721982
acts_upstream_of_or_within GO:0009952 anterior/posterior pattern specification PMID:10452853, PMID:16991118
acts_upstream_of_or_within GO:0032925 regulation of activin receptor signaling pathway PMID:8721982
enables GO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:1326537
enables GO:0019838 growth factor binding PMID:11459935, PMID:12414726
enables NOT GO:0050431 transforming growth factor beta binding PMID:1326537
PR:Q13705-1
hACVR2B/iso:ActR-IIB2
acts_upstream_of_or_within GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:8161782
PR:Q13705-2
hACVR2B/iso:ActR-IIB1
enables NOT GO:0016362 activin receptor activity, type II PMID:9916847
has_agent SO:0001587 stop_gained PMID:9916847
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1

PMID:8161782
PR:P27040-1 mACVR2B/iso:ActR-IIB1

PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3

PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4

PMID:1310075

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