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Protein Ontology Report - ROCK2

PR:000000121 - http://purl.obolibrary.org/obo/PR_000000121
Ontology Information
PRO ID PR:000000121 Show OBO stanza / PAF
PRO name Rho-associated protein kinase 2
Synonyms
PRO-short-label: ROCK2
EXACT: ROCK-II; Rho-associated, coiled-coil-containing protein kinase II; p164 ROCK-2; rho kinase 2; rho-associated, coiled-coil-containing protein kinase 2
Gene-based: KIAA0619
Definition A Rho-associated protein kinase that is a translation product of the human ROCK2 gene or a 1:1 ortholog thereof. [PRO:CNA]
PRO Category gene
Parent PR:000000024 Rho-associated protein kinase
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
gene 1 organism-gene 3
sequence 2 organism-sequence 3
modification 6 organism-modification 3
union 0
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:O75116-1
hROCK2/iso:1
capable_of GO:0031267 small GTPase binding PMID:11350930
capable_of GO:0004674 protein serine/threonine kinase activity PMID:9933571
located_in GO:0005622 intracellular anatomical structure PMID:16574662
participates_in GO:0051260 protein homooligomerization PMID:15291762
participates_in GO:0006468 protein phosphorylation PMID:9933571
PR:P70336-2
mROCK2/iso:2
capable_of GO:0004674 protein serine/threonine kinase activity PMID:17606625
participates_in GO:0006468 protein phosphorylation PMID:17606625
participates_in GO:0051149 positive regulation of muscle cell differentiation PMID:17606625
PR:000036477
hROCK2/iso:1/Clv:1
capable_of GO:0004674 protein serine/threonine kinase activity increased relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_in GO:0005622 intracellular anatomical structure PMID:15699075
participates_in GO:0030036 actin cytoskeleton organization PMID:15699075
participates_in GO:0006468 protein phosphorylation PMID:15699075
PR:000036478
hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
capable_of GO:0004674 protein serine/threonine kinase activity PMID:17446864
located_in GO:0005634 nucleus PMID:15302935
participates_in GO:0006468 protein phosphorylation PMID:17446864
PR:000036479
hROCK2/iso:1/Phos:2
Thr-1078, MOD:00047
participates_in GO:0006975 DNA damage induced protein phosphorylation PMID:17525332
Biological Process GO Term Protein Forms & Complexes Evidence
GO:0006468 protein phosphorylation PR:000036477 hROCK2/iso:1/Clv:1

PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
PMID:17446864
PR:O75116-1 hROCK2/iso:1

PMID:9933571
PR:P70336-2 mROCK2/iso:2

PMID:17606625
GO:0006975 DNA damage induced protein phosphorylation PR:000036479 hROCK2/iso:1/Phos:2
Thr-1078, MOD:00047
PMID:17525332
GO:0051149 positive regulation of muscle cell differentiation PR:P70336-2 mROCK2/iso:2

PMID:17606625
GO:0030036 actin cytoskeleton organization PR:000036477 hROCK2/iso:1/Clv:1

PMID:15699075
GO:0051260 protein homooligomerization PR:O75116-1 hROCK2/iso:1

PMID:15291762
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000036478 hROCK2/iso:1/Phos:1
Ser-1134/Ser-1137, MOD:00046
PMID:15302935
GO:0005622 intracellular anatomical structure PR:000036477 hROCK2/iso:1/Clv:1

PMID:15699075
PR:O75116-1 hROCK2/iso:1

PMID:16574662

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