Protein Ontology Report - hTGFB1/var:R218C PR:000000400 - http://purl.obolibrary.org/obo/PR_000000400

Ontology Information
PRO ID	PR:000000400 Show OBO stanza / PAF / GPI
PRO name	TGF-beta 1 sequence variant R218C (human)
Synonyms	PRO-short-label: EXACT: hTGFB1/var:R218C PRO-proteoform-std: EXACT: UniProtKB:P01137, Arg-218, CHEBI:29950 Other: EXACT: TGF-beta 1 sequence variant 3 (human)
Definition	A transforming growth factor beta-1 (human) that has a Cys residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29950. [PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN]
PRO Category	organism-sequence
Parent	PR:P01137 transforming growth factor beta-1 (human)
Taxon	NCBITaxon:9606 Homo sapiens
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	UniProtKB_VAR:VAR_017608

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000000400 hTGFB1/var:R218C Arg-218, CHEBI:29950 acts_upstream_of_or_within GO:0007179 transforming growth factor beta receptor signaling pathway PMID:12843182 acts_upstream_of_or_within GO:0043066 negative regulation of apoptotic process PMID:11062463, PMID:12493741, PMID:12843182 associated_with_disease_progression DOID:4997 Camurati-Engelmann disease PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182 enables GO:0008083 growth factor activity increased relative to PR:000002555 TGFB1/iso:1/UnMod PMID:11062463, PMID:12493741, PMID:12843182

top