PRO Entry Report - PR:000000623

Protein Ontology Report - hTGFB1/var:H222D/Clv:1

PR:000000623 - http://purl.obolibrary.org/obo/PR_000000623

Protein Forms Annotations

Ontology Information

PRO ID

PR:000000623 Show OBO stanza / PAF / GPI

PRO name

TGF-beta 1 sequence variant H222D cleaved 1 (human)

Synonyms

PRO-short-label:	EXACT:	hTGFB1/var:H222D/Clv:1
PRO-proteoform-std:	EXACT:	UniProtKB:P01137, 279-390, His-222, CHEBI:29958
Other:	EXACT:	TGF-beta 1 sequence variant 5 cleaved 1 (human)

Definition

A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958. [PRO:CNA, PRO:DAN]

PRO Category

organism-modification

Parent

PR:000021905 TGF-beta 1 sequence variant H222D, signal peptide removed form (human)

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000000623 hTGFB1/var:H222D/Clv:1 His-222, CHEBI:29958	acts_upstream_of_or_within	GO:0043066 negative regulation of apoptotic process	PMID:12493741
	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:12493741
	enables	GO:0008083 growth factor activity increased relative to PR:000000616 TGFB1/iso:1/mature	PMID:12493741
	located_in	GO:0005615 extracellular space	PMID:12493741

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005615 extracellular space	PR:000000623 hTGFB1/var:H222D/Clv:1 His-222, CHEBI:29958	PMID:12493741

top