| PRO ID |
PR:000000684
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/ PAF
|
| PRO name |
voltage-gated potassium channel subunit KQT |
| Synonyms |
| PRO-short-label: |
EXACT: |
fam:Kchan_sub-KQT |
|
| Definition |
A voltage-gated potassium channel protein that has a core domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. Unlike other voltage-gated potassium channels, these proteins lack the N-terminal tetramerization domain (T1), which encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Also, unique to this class is the presence of a carboxyl-terminal domain called the KCNQ voltage-gated potassium channel domain (Pfam:PF03520) or A-domain. Voltage-gated potassium channels are composed of tetramers of alpha subunits, with each alpha subunit containing a voltage sensor and contributing to the central pore. This pore is formed by these subunits that encircle a central ion conduction pathway. KQT channels are responsible for M-type potassium currents in the nervous and auditory systems and slow delayed rectifier K+ currents in the heart.
[PRO:CNA]
|
| PRO Category |
family |
| Parent |
PR:000044654 voltage-gated potassium channel protein |
| Term Hierarchy Visualization |
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