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Protein Ontology Report - fam:Kchan_shal_sub-a

PR:000000710 - http://purl.obolibrary.org/obo/PR_000000710
Ontology Information
PRO ID PR:000000710 Show OBO stanza
PRO name shal-related voltage-gated potassium channel alpha subunit
Synonyms
PRO-short-label: EXACT: fam:Kchan_shal_sub-a
Other: RELATED: A-type potassium channel | Kv4 | pore-forming Kv4 alpha subunits
Definition A voltage-gated potassium channel alpha subunit that is a constituent of the Kv4 channels, responsible for transient, voltage-dependent potassium currents (A currents) in the brain and heart. The unique motif KSCASE is absolutely conserved in all shal-related channel subunits. Mutations in this region drastically affect deactivation and inactivation. This motif is located in the cytoplasmic S4-S5 loop. In common with Kv2 and Kv3 channels, the tetramerization domain at the N terminus contains a zinc binding site. Kv.4 channels are modulated by Kv4 Channel Interacting Proteins (KChIPs1-4), which bind to the cytoplasmic N-terminal domain. [PMID:15555915]
PRO Category family
Parent PR:000000685 voltage-gated potassium channel alpha subunit
Term Hierarchy Visualization DAG     OLS     Cytoscape


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