| PRO ID |
PR:000000711
Show OBO stanza
|
| PRO name |
shaw-related voltage-gated potassium channel alpha subunit |
| Synonyms |
| PRO-short-label: |
EXACT: |
fam:Kchan_shaw_sub-a |
| Other: |
RELATED: |
Kv3 channel |
|
| Definition |
A voltage-gated potassium channel alpha subunit that is a constituent of Kv3 channels. These proteins are characterized by the high sequence conservation in the S5 segment which seems to determine the gating properties of the Kv3 channels: rightward shifted voltage dependence and fast deactivation rates. They also contain an ATM motif at the lysine-rich C-terminal region that is unique to this group. Kv3 channels are necessary for high-frequency, repetitive firing of action potentials. High activation threshold is a hallmark of Kv3 channels. They regulate rapid spiking, transmitter release and dendritic integration of many central neurons. In common with Kv2 and Kv4 channels, the tetramerization domain at the N terminus contains a zinc-binding site.
[PMID:11506885]
|
| PRO Category |
family |
| Parent |
PR:000000685 voltage-gated potassium channel alpha subunit |
| Term Hierarchy Visualization |
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