PRO Entry Report - PR:000001031

Protein Forms Annotations

Ontology Information

PRO ID

PR:000001031 Show OBO stanza / PAF

PRO name

ezrin

Synonyms

Definition

An erm protein that is a translation product of the human EZR gene or a 1:1 ortholog thereof. [PRO:CNA]

PRO Category

gene

Parent

PR:000001030 erm protein

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Term Hierarchy Visualization

DAG

OLS

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000036589 hEZR/iso:1/Phos:2 Ser-66, MOD:00046	enables	GO:0005515 protein binding with PR:000002696 WWOX/iso:1/UnMod	PMID:16438931
PR:000036590 hEZR/iso:1/Phos:3 Tyr-191, MOD:00048	enables	GO:0005515 protein binding with PR:P00523-1 chick-SRC/iso:1	PMID:15647376
PR:000036625 hEZR/iso:1/Phos:6 Tyr-354, MOD:00048\|Thr-567, MOD:00047	enables	GO:0003779 actin binding	PMID:18852256
	located_in	GO:0005886 plasma membrane	PMID:18852256
	located_in	GO:0002102 podosome	PMID:18852256
PR:000036592 hEZR/iso:1/Phos:5 Thr-567, MOD:00047	acts_upstream_of_or_within	GO:0001771 immunological synapse formation	PMID:18025306
	acts_upstream_of_or_within	GO:0051279 regulation of release of sequestered calcium ion into cytosol	PMID:18025306
	enables	GO:0005515 protein binding with PR:P43403 hZAP70	PMID:18025306
	located_in	GO:0045177 apical part of cell	PMID:16144865
	located_in	GO:0001772 immunological synapse	PMID:18025306

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0002102 podosome	PR:000036625 hEZR/iso:1/Phos:6 Tyr-354, MOD:00048\|Thr-567, MOD:00047	PMID:18852256
GO:0045177 apical part of cell	PR:000036592 hEZR/iso:1/Phos:5 Thr-567, MOD:00047	PMID:16144865
GO:0005886 plasma membrane	PR:000036625 hEZR/iso:1/Phos:6 Tyr-354, MOD:00048\|Thr-567, MOD:00047	PMID:18852256
GO:0001772 immunological synapse	PR:000036592 hEZR/iso:1/Phos:5 Thr-567, MOD:00047	PMID:18025306

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