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Protein Ontology Report - fam:rhodopsin

PR:000001094 -
Ontology Information
PRO ID PR:000001094 Show OBO stanza
PRO name rhodopsin-like G-protein coupled receptor
PRO-short-label: EXACT: fam:rhodopsin
Other: EXACT: class 1 G-protein coupled receptor | class A G-protein coupled receptor
Definition A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions. [PMID:12761335, PRO:DAN, PRO:WCB]
Comment Classification based on GRAFS system. [PMID:12761335]
PRO Category family
Parent PR:000030035 G-protein coupled receptor
Term Hierarchy Visualization DAG     OLS     Cytoscape