PRO Entry Report - PR:000025933

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000025933 Show OBO stanza / PAF / GPI

PRO name

smad2-smad4 protein complex 1 (human)

Synonyms

PRO-short-label:

EXACT:

h(pSMAD2:SMAD4):1

Definition

A smad2-smad4 protein complex 1 whose components are encoded in the genome of human. [PRO:CNA]

PRO Category

organism-complex

Parent

PR:000025967 smad2-smad4 protein complex 1

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	Reactome:R-HSA-206827

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000025933	PR:Q13485	mothers against decapentaplegic homolog 4 (human)	hSMAD4	A smad4 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13485]	1
PR:000025933	PR:000025934	smad2 isoform Long phosphorylated 1 (human)	hSMAD2/iso:Long/Phos:1	A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966]	2

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000025933 smad2-smad4 protein complex 1 (human)	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:8752209, PMID:8980228
	located_in	GO:0005829 cytosol	Reactome:REACT_7344
	located_in	GO:0005654 nucleoplasm	Reactome:REACT_7382

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005829 cytosol	PR:000025933 smad2-smad4 protein complex 1 (human)	Reactome:REACT_7344
GO:0005654 nucleoplasm	PR:000025933 smad2-smad4 protein complex 1 (human)	Reactome:REACT_7382

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