PRO Entry Report - PR:000025936

Protein Ontology Report - hSMAD2/iso:Long/Phos:3

PR:000025936 - http://purl.obolibrary.org/obo/PR_000025936

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000025936 Show OBO stanza / PAF / GPI

PRO name

smad2 isoform Long phosphorylated 3 (human)

Synonyms

PRO-short-label:	EXACT:	hSMAD2/iso:Long/Phos:3
PRO-proteoform-std:	EXACT:	UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046

Definition

A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046. [PMID:11027280]

Comment

Kinase=("CAMK-II"; PR:000003197; Ser-240). Kinase=("TGFBR1"; PR:000025963; Ser-465/Ser-467).

PRO Category

organism-modification

Parent

PR:000000652 smad2 isoform Long phosphorylated 3

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

hSMAD2/iso:Long/Phos:3 forms found in complexes

hSMAD2/iso:Long/Phos:3 Component	Complexes
PR:000025936 hSMAD2/iso:Long/Phos:3	PR:000025947 smad2-smad4 protein complex 4 (human)

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000025936 hSMAD2/iso:Long/Phos:3 Ser-240/Ser-465/Ser-467, MOD:00046	acts_upstream_of_or_within	GO:0007165 signal transduction	PMID:11027280
	acts_upstream_of_or_within	GO:0007183 SMAD protein complex assembly	PMID:11027280
	enables	GO:0046332 SMAD binding with PR:Q13485 hSMAD4	PMID:11027280
	enables	NOT GO:0003713 transcription coactivator activity	PMID:11027280
	located_in	GO:0005737 cytoplasm	PMID:11027280

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005737 cytoplasm	PR:000025936 hSMAD2/iso:Long/Phos:3 Ser-240/Ser-465/Ser-467, MOD:00046	PMID:11027280

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