PRO Entry Report - PR:000025942

Protein Ontology Report - mSMAD2/iso:Long/Phos:1

PR:000025942 - http://purl.obolibrary.org/obo/PR_000025942

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000025942 Show OBO stanza / PAF / GPI

PRO name

smad2 isoform Long phosphorylated 1 (mouse)

Synonyms

PRO-short-label:	EXACT:	mSMAD2/iso:Long/Phos:1
PRO-proteoform-std:	EXACT:	UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046

Definition

A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046. [PMID:8980228, PMID:9346966]

Comment

Kinase=("TGFBR1"; PR:000025976; Ser-465/Ser-467).

PRO Category

organism-modification

Parent

PR:000000650 smad2 isoform Long phosphorylated 1

Taxon

NCBITaxon:10090 Mus musculus

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

mSMAD2/iso:Long/Phos:1 forms found in complexes

mSMAD2/iso:Long/Phos:1 Component	Complexes
PR:000025942 mSMAD2/iso:Long/Phos:1	PR:000025944 smad2-smad4 protein complex 1 (mouse)

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000025942 mSMAD2/iso:Long/Phos:1 Ser-465/Ser-467, MOD:00046	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:11262418
	acts_upstream_of_or_within	GO:0007165 signal transduction	PMID:11262418
	enables	GO:0003713 transcription coactivator activity	PMID:15282343
	enables	GO:0046332 SMAD binding with PR:P97471 mSMAD4	PMID:11043574
	located_in	GO:0005634 nucleus	PMID:11557747

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005634 nucleus	PR:000025942 mSMAD2/iso:Long/Phos:1 Ser-465/Ser-467, MOD:00046	PMID:11557747

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