PRO Entry Report - PR:000035702

Protein Forms Complex Annotations

Ontology Information

PRO ID

PR:000035702 Show OBO stanza / PAF / GPI

PRO name

CD14 molecule isoform 1 cleaved 2 GPI-anchored form (human)

Synonyms

PRO-short-label:	EXACT:	hCD14/iso:1/Clv:2/anchored
PRO-proteoform-std:	EXACT:	UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167
PRO-proteoform-ftid:	EXACT:	PRO_0000020885, Asn-345, MOD:00167
Other:	EXACT:	GPI-N345-CD14 (human) \| GPI-anchored form of CD14 (human)

Definition

A CD14 molecule isoform 1 cleaved 2 GPI-anchored form in human. UniProtKB:P08571-1, 20-345, Asn-345, MOD:00167. [Reactome:R-HSA-166033, Reactome:R-HSA-2201284]

PRO Category

organism-modification

Parent

PR:000002149 CD14 molecule isoform 1 cleaved 2 GPI-anchored form

Taxon

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	Reactome:R-HSA-166033, Reactome:R-HSA-2201284

Interactive Sequence View Select/align proteoforms across species

Protein Forms

PRO ID & Category Annotation Complex	Name	Short Label	Definition & Comment

hCD14/iso:1/Clv:2/anchored forms found in complexes

hCD14/iso:1/Clv:2/anchored Component	Complexes
PR:000035702 hCD14/iso:1/Clv:2/anchored	PR:000027208 ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored	PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored	PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored	PR:000036022 traf3:ticam1:ticam2:activated TLR4 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored	PR:000037464 LPS:GPI-anchored CD14 complex (human)
PR:000035702 hCD14/iso:1/Clv:2/anchored	PR:000025773 lipopolysaccharide receptor complex 3 (human)

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000035702 hCD14/iso:1/Clv:2/anchored Asn-345, MOD:00167	acts_upstream_of_or_within	GO:0034142 toll-like receptor 4 signaling pathway	Reactome:REACT_6894
	located_in	GO:0005886 plasma membrane	PMID:2779588, PMID:3385210, PMID:9665271
	located_in	GO:0005886 plasma membrane	Reactome:REACT_7740

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005886 plasma membrane	PR:000035702 hCD14/iso:1/Clv:2/anchored Asn-345, MOD:00167	PMID:2779588, PMID:3385210, PMID:9665271
GO:0005886 plasma membrane	PR:000035702 hCD14/iso:1/Clv:2/anchored Asn-345, MOD:00167	Reactome:REACT_7740

top