PRO Entry Report - PR:000035740

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000035740 Show OBO stanza / PAF / GPI

PRO name

free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)

Synonyms

Other:	EXACT:	pUb-TRAF6:TAB1:TAB2/TAB3:free polyubiquitin chain : phospho-TAK1 (human)
	RELATED:	K63-pUb-TRAF6:free K63-linked pUb:activated TAK1 complex (human)

Definition

A free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex whose components are encoded in the genome of human. [Reactome:R-HSA-847073]

Comment

Requested by=TLR.

PRO Category

organism-complex

Parent

PR:000035739 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex

Taxon

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Related Cross References
DB identifiers	Reactome:R-HSA-847073

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000035740	PR:Q15750	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)	hTAB1	A TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 that is encoded in the genome of human. [PRO:CNA]	2
	PR:000027103	mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human)	fam:hTAB2-hTAB3	A mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 that is encoded in the genome of human. [PMID:15327770, PRO:CNA]	2
	PR:000035736	mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 (human)	hMAP3K7/Phos:1	A mitogen-activated protein kinase kinase kinase 7 phosphorylated 1 in human. UniProtKB:O43318, Thr-184/Thr-187, MOD:00047. [PRO:DNx, UniProtKB:O43318]	2
	PR:000035714	TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)	hTRAF6/K63polyUbiq:1	A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772. [PRO:DAN, UniProtKB:Q9Y4K3]	2
	PR:000035732	K63-polyubiquitin (human)	hK63polyUbiq	A K63-polyubiquitin in human. [Reactome:R-HSA-450152, Reactome:R-HSA-5682839, Reactome:R-HSA-6782513]	2

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_23131
	acts_upstream_of_or_within	GO:0002755 MyD88-dependent toll-like receptor signaling pathway	Reactome:REACT_23131
	located_in	GO:0005829 cytosol	Reactome:REACT_23131

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005829 cytosol	PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)	Reactome:REACT_23131

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