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Protein Ontology Report - (vir)dsRNA:TLR3

PR:000037302 - http://purl.obolibrary.org/obo/PR_000037302
Ontology Information
PRO ID PR:000037302 Show OBO stanza / PAF
PRO name viral dsRNA:TLR3 complex
Synonyms
PRO-short-label: EXACT: (vir)dsRNA:TLR3
Definition A macromolecular complex that is composed of viral double stranded RNA (dsRNA) and a homodimer of TLR3. Viral dsRNA triggers an antiviral pathway mediated by Toll-like receptor 3. TLR3 dimerization occurs upon ligand binding to positively charged residues on the ectodomain termini of TLR3 wich are responsible for the interaction with sugar-phosphate groups of dsRNA. [PMID:18420935, PMID:20861016, PRO:CNA, PRO:DAN, Reactome:R-HSA-167985]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 3
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037303 PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1
PR:000037302 PR:000001154 Toll-like receptor 3 TLR3 A Toll-like receptor that is a translation product of the human TLR3 gene or a 1:1 ortholog thereof. [PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1
PR:000037461 PR:Q0PQ88 Toll-like receptor 3 (chicken) chick-TLR3 A Toll-like receptor 3 that is encoded in the genome of chicken. [PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1
PR:000037304 PR:000037789 Toll-like receptor 3, signal peptide removed form (mouse) mTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905. [ECO:0000250, PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037303
viral dsRNA:TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000037304
viral dsRNA:TLR3 complex (mouse)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway PMID:18420935
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:18420935
PR:000037461
viral dsRNA:TLR3 complex (chicken)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_24923
located_in GO:0010008 endosome membrane Reactome:REACT_24923
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037303 viral dsRNA:TLR3 complex (human)

Reactome:REACT_6783
PR:000037461 viral dsRNA:TLR3 complex (chicken)

Reactome:REACT_24923

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