PRO Entry Report - PR:000037309

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000037309 Show OBO stanza / PAF

PRO name

traf3:ticam1:activated TLR3 complex

Synonyms

Other:

EXACT:

TLR3TLR3dsRNATriftraf3 | TRAF3:TRIF:activated TLR3

Definition

A protein-containing complex that is composed of activated Toll-like receptor 3, TICAM1 (TRIF) and TRAF3. [PMID:16306937]

Comment

Requested by=TLR.

PRO Category

complex

Parent

GO:0032991 protein-containing complex

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
complex	1	organism-complex	2

Term Hierarchy Visualization

DAG

OLS

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000037310	PR:Q13114	TNF receptor-associated factor 3 (human)	hTRAF3	A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA]	2
	PR:Q8IUC6	TIR domain-containing adapter molecule 1 (human)	hTICAM1	A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA]	2
	PR:000037305	Toll-like receptor 3, signal peptide removed form (human)	hTLR3/SigPep-	A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341]	2
	CHEBI:67208	dsRNA	dsRNA	A double stranded ribonucleic acid. [None]	1
PR:000037311	PR:Q60803	TNF receptor-associated factor 3 (mouse)	mTRAF3	A TNF receptor-associated factor 3 that is encoded in the genome of mouse. [OMA:Q60803, PRO:CNA]	2
	PR:Q80UF7	TIR domain-containing adapter molecule 1 (mouse)	mTICAM1	A TIR domain-containing adapter molecule 1 that is encoded in the genome of mouse. [OMA:Q80UF7, PRO:CNA]	2
	PR:000037789	Toll-like receptor 3, signal peptide removed form (mouse)	mTLR3/SigPep-	A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905. [ECO:0000250, PRO:CNA]	2
	CHEBI:67208	dsRNA	dsRNA	A double stranded ribonucleic acid. [None]	1

Functional Annotation

PRO Term	GO Annotation		Evidence
PR:000037310 traf3:ticam1:activated TLR3 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783
PR:000037311 traf3:ticam1:activated TLR3 complex (mouse)	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	PMID:16306936, PMID:16306937

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0010008 endosome membrane	PR:000037310 traf3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783

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