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Protein Ontology Report - tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex

PR:000037312 - http://purl.obolibrary.org/obo/PR_000037312
Ontology Information
PRO ID PR:000037312 Show OBO stanza / PAF
PRO name tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex
Synonyms
Other: EXACT: TLR3TLR3dsRNATriftraf3TBK1tankIKKe
Definition A protein-containing complex that is composed of activated Toll-like receptor 3, TICAM1 (TRIF), TRAF3, TANK, TBK1, and IKKE. [PMID:12133833, PMID:17327220, TLR:AMM]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037313 PR:Q9WUN2 serine/threonine-protein kinase TBK1 (mouse) mTBK1 A serine/threonine-protein kinase TBK1 that is encoded in the genome of mouse. [OMA:Q9WUN2, PRO:CNA]
PR:Q9R0T8 inhibitor of nuclear factor kappa-B kinase subunit epsilon (mouse) mIKBKE An inhibitor of nuclear factor kappa-B kinase subunit epsilon that is encoded in the genome of mouse. [OMA:Q9R0T8, PRO:CNA]
PR:P70347 TRAF family member-associated NF-kappa-B activator (mouse) mTANK A TRAF family member-associated NF-kappa-B activator that is encoded in the genome of mouse. [OMA:P70347, PRO:CNA]
PR:Q60803 TNF receptor-associated factor 3 (mouse) mTRAF3 A TNF receptor-associated factor 3 that is encoded in the genome of mouse. [OMA:Q60803, PRO:CNA] 2
PR:Q80UF7 TIR domain-containing adapter molecule 1 (mouse) mTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of mouse. [OMA:Q80UF7, PRO:CNA] 2
PR:000037789 Toll-like receptor 3, signal peptide removed form (mouse) mTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in mouse. UniProtKB:Q99MB1, 26-905. [ECO:0000250, PRO:CNA] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037313
tbk1:tank:ikke:traf3:ticam1:activated TLR3 complex (mouse)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway PMID:12133833, PMID:17327220

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