PRO Entry Report - PR:000037356

Protein Ontology Report - IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

PR:000037356 - http://purl.obolibrary.org/obo/PR_000037356

Complex Forms Complex Subunits Annotations

Ontology Information

PRO ID

PR:000037356 Show OBO stanza / PAF / GPI

PRO name

IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Synonyms

Other:

activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-TBK1/p-IKKE:IRF7 (human)

Definition

An IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex whose components are encoded in the genome of human. [PMID:14517278, PMID:14739303, PMID:16281057, PRO:VS, Reactome:REACT_27000]

Comment

Requested by=TLR.

PRO Category

organism-complex

Parent

PR:000037355 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex

Taxon

NCBITaxon:9606 Homo sapiens

Terms by PRO Category

Retrieve All terms OBO Stanza / PAF

Organism-Specific
Category	Number of Terms
organism-complex	1

Term Hierarchy Visualization

DAG

OLS

Cytoscape

Complex Forms

PRO ID & Category Annotation Subunits	Name	Short Label	Definition & Comment

Complex Subunits

Complex	PRO ID	Name	Short Label	Definition	Number in Complex
PR:000037356	PR:Q13114	TNF receptor-associated factor 3 (human)	hTRAF3	A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA]	2
	PR:Q8IUC6	TIR domain-containing adapter molecule 1 (human)	hTICAM1	A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA]	2
	PR:000028695	serine/threonine-protein kinase TBK1 phosphorylated 1 (human)	hTBK1/Phos:1	A serine/threonine-protein kinase TBK1 phosphorylated 1 in human. UniProtKB:Q9UHD2, Ser-172, MOD:00046. [PRO:CNA, Reactome:R-HSA-450290]	2
	PR:000028704	interferon regulatory factor 7 unmodified form (human)	hIRF7/UnMod	An interferon regulatory factor 7 unmodified form in human. [PRO:CNA]	2
	PR:000037305	Toll-like receptor 3, signal peptide removed form (human)	hTLR3/SigPep-	A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341]	2
	PR:000036032	TNF receptor-associated factor 3 K63-polyubiquitinated form (human)	hTRAF3/K63polyUbiq+	A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772. [Reactome:R-HSA-936402]	2
	CHEBI:67208	dsRNA	dsRNA	A double stranded ribonucleic acid. [None]	1

Functional Annotation

PRO Centric View
GO Centric View

PRO Term	GO Annotation		Evidence
PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	acts_upstream_of_or_within	GO:0002756 MyD88-independent toll-like receptor signaling pathway	Reactome:REACT_6783
	acts_upstream_of_or_within	GO:0034138 toll-like receptor 3 signaling pathway	Reactome:REACT_6783
	located_in	GO:0010008 endosome membrane	Reactome:REACT_6783

Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0010008 endosome membrane	PR:000037356 IRF7:p-tbk1:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)	Reactome:REACT_6783

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