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Protein Ontology Report - IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex

PR:000037359 - http://purl.obolibrary.org/obo/PR_000037359
Ontology Information
PRO ID PR:000037359 Show OBO stanza / PAF
PRO name IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex
Synonyms
Other: RELATED: activated TLR3:TRIF:K63-poly-Ub-TRAF3:p-IKK epsilon:IRF7
Definition A protein-containing complex that is composed of activated Toll-like receptor 3 (TLR3), Ticam1 (TRIF), TRAF3 linked to Lys-63 polyubiquitin, phosphorylated IKK epsilon and unphosphosrylated IRF7. [PMID:14517278, PMID:14739303, PMID:16281057, Reactome:REACT_27000]
Comment Requested by=TLR.
PRO Category complex
Parent GO:0032991 protein-containing complex
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Independent Organism-Specific
Category Number of Terms Category Number of Terms
complex 1 organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037360 PR:Q13114 TNF receptor-associated factor 3 (human) hTRAF3 A TNF receptor-associated factor 3 that is encoded in the genome of human. [PRO:CNA] 2
PR:Q8IUC6 TIR domain-containing adapter molecule 1 (human) hTICAM1 A TIR domain-containing adapter molecule 1 that is encoded in the genome of human. [PRO:CNA] 2
PR:000028704 interferon regulatory factor 7 unmodified form (human) hIRF7/UnMod An interferon regulatory factor 7 unmodified form in human. [PRO:CNA] 2
PR:000028691 inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human) hIKBKE/Phos:1 An inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 in human. Example: UniProtKB:Q14164-1, Ser-172, MOD:00046. [PMID:10421793, PRO:CNA, Reactome:R-HSA-450278] 2
PR:000037305 Toll-like receptor 3, signal peptide removed form (human) hTLR3/SigPep- A Toll-like receptor 3, signal peptide removed form in human. Example: UniProtKB:O15455-1, 24-904. [PMID:15340161, PRO:CNA, Reactome:R-HSA-1678955, Reactome:R-HSA-1679057, Reactome:R-HSA-167941, Reactome:R-HSA-2000341] 2
PR:000036032 TNF receptor-associated factor 3 K63-polyubiquitinated form (human) hTRAF3/K63polyUbiq+ A TNF receptor-associated factor 3 K63-polyubiquitinated form in human. UniProtKB:Q13114, PR:000044772. [Reactome:R-HSA-936402] 2
CHEBI:67208 dsRNA dsRNA A double stranded ribonucleic acid. [None] 1


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037360
IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000037360 IRF7:p-IKKE:K63-poly-Ub-TRAF3:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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