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Protein Ontology Report - chick-TLR4actv

PR:000037474 - http://purl.obolibrary.org/obo/PR_000037474
Ontology Information
PRO ID PR:000037474 Show OBO stanza / PAF / GPI
PRO name activated TLR4 complex (chicken)
Synonyms
PRO-short-label: EXACT: chick-TLR4actv
Other: EXACT: LY96:LPS:TLR4 complex (chicken) | MD2:LPS:TLR4 (chicken) | chick-(LY96:LPS:TLR4)
Definition An activated TLR4 complex whose components are encoded in the genome of chicken. LPS binding to Toll-like receptor 4 results in dimerization of the TLR4 associated with MD2. [PMID:18768894, PMID:24034933, Reactome:R-GGA-433789]
Comment Requested by=TLR.
PRO Category organism-complex
Parent PR:000036076 activated TLR4 complex
Taxon NCBITaxon:9031 Gallus gallus
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape


Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037474 PR:A0A1D5NZX9 lymphocyte antigen 96 (chicken) chick-LY96 A lymphocyte antigen 96 that is encoded in the genome of chicken. [OMA:A0A1D5NZX9, TLR:AMM] 2
PR:Q7ZTG5 Toll-like receptor 4 (chicken) chick-TLR4 A Toll-like receptor 4 that is encoded in the genome of chicken. [PMID:18768894, PMID:20483729, PRO:CNA] 2
CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037474
activated TLR4 complex (chicken)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway PMID:18768894
acts_upstream_of_or_within GO:0051607 defense response to virus PMID:24034933
acts_upstream_of_or_within GO:0045429 positive regulation of nitric oxide biosynthetic process PMID:24034933
located_in GO:0005886 plasma membrane Reactome:REACT_25442
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005886 plasma membrane PR:000037474 activated TLR4 complex (chicken)

Reactome:REACT_25442

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