Protein Ontology Report - MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse) PR:000037481 - http://purl.obolibrary.org/obo/PR_000037481

Ontology Information
PRO ID	PR:000037481 Show OBO stanza / GPI
PRO name	MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
Synonyms	Other: EXACT: MyD88:MAL:PI(4,5)P2:BTK:activated TLR4 (mouse) RELATED: MyD88:Mal complexed with the activated TLR (mouse)
Definition	A MYD88:TIRAP:PIP2:BTK:activated TLR4 complex that is composed of MyD88, PI(4,5)P2, TIRAP/MAL, BTK, TLR4, MD2, and LPS in mouse. [TLR:AMM]
Comment	Evidence=(ECO:0000088, based on PR:000037446). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial trasnfer of LPS. PMID:21441935 shows interaction of MYD88 with BTK.
PRO Category	organism-complex
Parent	PR:000037488 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex
Taxon	NCBITaxon:10090 Mus musculus
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-complex 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Complex Forms Display Category: All All organism-complex
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits

Complex PRO ID Name Short Label Definition Number in Complex PR:000037481 PR:P35991 tyrosine-protein kinase BTK (mouse) mBTK A tyrosine-protein kinase BTK that is encoded in the genome of mouse. [OMA:P35991, PRO:WCB] 2 PR:P22366-1 myeloid differentiation primary response protein MyD88 isoform 1 (mouse) mMYD88/iso:1 A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse. [PMID:11909531, PRO:CNA] 2 PR:Q99JY1 Toll/interleukin-1 receptor domain-containing adapter protein (mouse) mTIRAP A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of mouse. [OMA:Q99JY1, PRO:CNA] 2 PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2 PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2 CHEBI:16412 lipopolysaccharide lipopolysaccharide Natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). [fake:1] 2 CHEBI:18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. [None]

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