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Protein Ontology Report - MD2:GB4:TLR4 complex (mouse)

PR:000037794 - http://purl.obolibrary.org/obo/PR_000037794
Ontology Information
PRO ID PR:000037794 Show OBO stanza / PAF
PRO name MD2:GB4:TLR4 complex (mouse)
Definition A protein-containing complex that is composed of two copies of the proteins Toll-like receptor 4 (TLR4) and the lymphocyte antigen 96 (LY96/MD2), and two globotetraosylceramide (GB4) molecules in mouse. [PMID:23471986, PRO:CNA]
Comment Note: PMID:23471986, binding of Gb4 to the LPS receptor TLR4-MD-2 was demonstrated by coprecipitation of Gb4 with recombinant MD-2 and by native PAGE. Evidence=(ECO:0000269, based on PMID:23471986).
PRO Category organism-complex
Parent GO:0032991 protein-containing complex
Taxon NCBITaxon:10090 Mus musculus
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-complex 1
Term Hierarchy Visualization DAG     OLS     Cytoscape

Complex Forms
PRO ID & Category Annotation Subunits Name Short Label Definition & Comment

Complex Subunits
Complex PRO ID Name Short Label Definition Number in Complex
PR:000037794 PR:000027171 lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mLY96/iso:1/SigPep-/NGlyco:1 A lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form in mouse that has been N-glycosylated on Asn residues at positions 26, 114, and 150 of the amino acid sequence represented by UniProtKB:Q9JHF9-1. UniProtKB:Q9JHF9-1, 19-160, Asn-26/Asn-114/Asn-150, MOD:00160. [PMID:17803912, PRO:CNA] 2
PR:000027172 Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse) mTLR4/iso:1/SigPep-/NGlyco:1 A Toll-like receptor 4 isoform 1, signal peptide removed form in mouse that has been N-glycosylated on Asn residues at positions 34, 75, 172, 204, 237, 307, 492, 524 and 572 of the amino acid sequence represented by UniProtKB:Q9QUK6-1. UniProtKB:Q9QUK6-1, 26-835, Asn-34/Asn-75/Asn-172/Asn-204/Asn-237/Asn-307/Asn-492/Asn-524/Asn-572, MOD:00160. [PMID:17803912, PRO:CNA] 2
CHEBI:18259 N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component. [None] 2


Functional Annotation
PRO Term GO Annotation Evidence
PR:000037794
MD2:GB4:TLR4 complex (mouse)
acts_upstream_of_or_within GO:0034144 negative regulation of toll-like receptor 4 signaling pathway PMID:23471986
enables NOT GO:0001530 lipopolysaccharide binding PMID:23471986

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