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Protein Ontology Report - hCHUK

PR:O15111 - http://purl.obolibrary.org/obo/PR_O15111
This page represents a class of proteins encompassing all the protein products of the CHUK gene in human.
Ontology Information
PRO ID PR:O15111 Show OBO stanza / PAF / GPI
PRO name inhibitor of nuclear factor kappa-B kinase subunit alpha (human)
Synonyms
PRO-short-label: EXACT: hCHUK
Gene-based: RELATED: CHUK | IKKA | TCF16
Other: EXACT: I-kappa-B kinase 1 (human) | I-kappa-B kinase alpha (human) | IKK-A (human) | IKK-alpha (human) | IKK1 (human) | IkBKA (human) | IkappaB kinase (human) | NFKBIKA (human) | TCF-16 (human) | conserved helix-loop-helix ubiquitous kinase (human) | nuclear factor NF-kappa-B inhibitor kinase alpha (human) | transcription factor 16 (human)
Definition An inhibitor of nuclear factor kappa-B kinase subunit alpha that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15111]
PRO Category organism-gene
Parent PR:000001775 inhibitor of nuclear factor kappa-B kinase subunit alpha
Gene Template HGNC:1974 CHUK
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 1
organism-modification 2
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hCHUK forms found in complexes
hCHUK Component Complexes
PR:000026823 hCHUK/iso:1/Phos:1 PR:000035833 activated IkappaB kinase complex (human)
PR:O15111 hCHUK PR:000026457 IkappaB kinase complex (human)
PR:O15111 hCHUK PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
PR:O15111 hCHUK PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037364
IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)
acts_upstream_of_or_within GO:0034138 toll-like receptor 3 signaling pathway Reactome:REACT_6783
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6783
located_in GO:0010008 endosome membrane Reactome:REACT_6783
PR:000026457
IkappaB kinase complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
PR:000036053
IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)
acts_upstream_of_or_within GO:0002756 MyD88-independent toll-like receptor signaling pathway Reactome:REACT_6809
located_in GO:0010008 endosome membrane Reactome:REACT_26016
PR:000035833
activated IkappaB kinase complex (human)
acts_upstream_of_or_within GO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0010008 endosome membrane PR:000036053 IKK complex:K63-pUb-rip1:ticam1:ticam2:activated TLR4 complex (human)

Reactome:REACT_26016
PR:000037364 IKK complex:K63-pUb-rip1:ticam1:activated TLR3 complex (human)

Reactome:REACT_6783

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