Protein Ontology Report - hROCK2 PR:O75116 - http://purl.obolibrary.org/obo/PR_O75116

This page represents a class of proteins encompassing all the protein products of the ROCK2 gene in Homo sapiens.

Ontology Information
PRO ID	PR:O75116 Show OBO stanza / PAF / GPI
PRO name	Rho-associated protein kinase 2 (human)
Synonyms	PRO-short-label: EXACT: hROCK2 Gene-based: RELATED: KIAA0619 | ROCK2 Other: EXACT: ROCK-II (human) | Rho kinase 2 (human) | Rho-associated, coiled-coil-containing protein kinase 2 (human) | Rho-associated, coiled-coil-containing protein kinase II (human) | p164 ROCK-2 (human)
Definition	A Rho-associated protein kinase 2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:O75116]
PRO Category	organism-gene
Parent	PR:000000121 Rho-associated protein kinase 2
Gene Template	HGNC:10252 ROCK2
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100457, Reactome:R-HSA-419058, Reactome:R-HSA-4687775, UniProtKB:O75116

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:O75116-1 hROCK2/iso:1 acts_upstream_of_or_within GO:0006468 protein phosphorylation PMID:9933571 acts_upstream_of_or_within GO:0051260 protein homooligomerization PMID:15291762 enables GO:0031267 small GTPase binding PMID:11350930 enables GO:0004674 protein serine/threonine kinase activity PMID:9933571 located_in GO:0005622 intracellular anatomical structure PMID:16574662 PR:000036477 hROCK2/iso:1/Clv:1 acts_upstream_of_or_within GO:0006468 protein phosphorylation PMID:15699075 acts_upstream_of_or_within GO:0030036 actin cytoskeleton organization PMID:15699075 enables GO:0004674 protein serine/threonine kinase activity increased relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075 located_in GO:0005622 intracellular anatomical structure PMID:15699075 PR:000036478 hROCK2/iso:1/Phos:1 Ser-1134/Ser-1137, MOD:00046 acts_upstream_of_or_within GO:0006468 protein phosphorylation PMID:17446864 enables GO:0004674 protein serine/threonine kinase activity PMID:17446864 located_in GO:0005634 nucleus PMID:15302935 PR:000036479 hROCK2/iso:1/Phos:2 Thr-1078, MOD:00047 acts_upstream_of_or_within GO:0042770 signal transduction in response to DNA damage PMID:17525332 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005634 nucleus PR:000036478 hROCK2/iso:1/Phos:1 Ser-1134/Ser-1137, MOD:00046 PMID:15302935 GO:0005622 intracellular anatomical structure PR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075 PR:O75116-1 hROCK2/iso:1 PMID:16574662

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