Protein Ontology Report - hEGFR PR:P00533 - http://purl.obolibrary.org/obo/PR_P00533

This page represents a class of proteins encompassing all the protein products of the EGFR gene in Homo sapiens.

Ontology Information
PRO ID	PR:P00533 Show OBO stanza / PAF / GPI
PRO name	epidermal growth factor receptor (human)
Synonyms	PRO-short-label: EXACT: hEGFR Gene-based: RELATED: EGFR | ERBB | ERBB1 | HER1 Other: EXACT: proto-oncogene c-ErbB-1 (human) | receptor tyrosine-protein kinase erbB-1 (human)
Definition	An epidermal growth factor receptor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P00533]
PRO Category	organism-gene
Parent	PR:000006933 epidermal growth factor receptor
Gene Template	HGNC:3236 EGFR
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 4 organism-modification 20
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100124, UniProtKB:P00533

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hEGFR forms found in complexes
hEGFR Component Complexes PR:000028422 hEGFR/SigPep- PR:000028451 L1-EGFR trans-heterodimer (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000049851 hEGFR/SigPep-/Phos:4 Ser-768, MOD:00046 enables GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049852 hEGFR/SigPep-/UnPhos:4 PMID:10347170 PR:000049849 hEGFR/SigPep-/Phos:3 Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046 enables GO:0005515 protein binding decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 with PR:P00533 hEGFR PMID:10347170 enables GO:0004713 protein tyrosine kinase activity decreased relative to PR:000049850 hEGFR/SigPep-/UnPhos:3 PMID:10347170 PR:000027479 hEGFR/iso:1/SigPep-/Phos:1 Tyr-869, MOD:00048 acts_upstream_of_or_within GO:0034504 protein localization to nucleus PMID:18789131 located_in GO:0005634 nucleus PMID:18789131 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005634 nucleus PR:000027479 hEGFR/iso:1/SigPep-/Phos:1 Tyr-869, MOD:00048 PMID:18789131

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