Protein Ontology Report - hMYC PR:P01106 - http://purl.obolibrary.org/obo/PR_P01106

This page represents a class of proteins encompassing all the protein products of the MYC gene in Homo sapiens.

Ontology Information
PRO ID	PR:P01106 Show OBO stanza / PAF / GPI
PRO name	Myc proto-oncogene protein (human)
Synonyms	PRO-short-label: EXACT: hMYC Gene-based: RELATED: BHLHE39 | MYC Other: EXACT: class E basic helix-loop-helix protein 39 (human) | proto-oncogene c-Myc (human) | transcription factor p64 (human)
Definition	A c-myc protein that is encoded in the genome of human. [PRO:CNA, UniProtKB:P01106]
PRO Category	organism-gene
Parent	PR:000000084 c-myc protein
Gene Template	HGNC:7553 MYC
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 2 organism-modification 8
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-188379, Reactome:R-HSA-4411332, UniProtKB:P01106

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hMYC forms found in complexes
hMYC Component Complexes PR:000026033 hMYC/iso:1/Ac:1 PR:000026035 Myc-max acetylated complex (human) PR:000026038 hMYC/iso:1/UnMod PR:000026039 Myc-max complex 1 (human) PR:P01106 hMYC PR:000025987 Myc-max complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000026039 Myc-max complex 1 (human) enables GO:0070888 E-box binding PMID:15003254 PR:P01106-1 hMYC/iso:1 acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:10962037 acts_upstream_of_or_within GO:0008283 cell population proliferation PMID:10962037 acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:16908182, PMID:2006410 enables GO:0005515 protein binding PMID:12706874 enables GO:0003700 DNA-binding transcription factor activity PMID:16908182, PMID:2006410 part_of GO:0005667 transcription factor complex PMID:16908182, PMID:2006410 PR:P01106-2 hMYC/iso:2 enables GO:0003700 DNA-binding transcription factor activity PMID:3277717 PR:000026033 hMYC/iso:1/Ac:1 Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394 enables GO:0003700 DNA-binding transcription factor activity PMID:16126174 located_in GO:0005634 nucleus PMID:16126174 part_of GO:0005667 transcription factor complex PMID:16126174 PR:000026035 Myc-max acetylated complex (human) enables GO:0070888 E-box binding PMID:16126174 enables GO:0008134 transcription factor binding with PR:Q13105 hZBTB17 PMID:16126174 PR:000026055 hMYC/iso:1/Phos:3 Ser-62/Ser-71, MOD:00046 acts_upstream_of_or_within GO:0045766 positive regulation of angiogenesis PMID:12676581 located_in GO:0005634 nucleus PMID:12676581 PR:000026054 hMYC/iso:1/Phos:2 Thr-58, MOD:00047|Ser-62, MOD:00046 enables NOT GO:0003700 DNA-binding transcription factor activity PMID:7623799 PR:000036448 hMYC/iso:1/Phos:1 Ser-62, MOD:00046 enables GO:0005515 protein binding with PR:O15169-1 hAXIN1/iso:1 PMID:19131971 PR:000026051 hMYC/iso:1/OGlyco:1 Thr-58, MOD:00806 acts_upstream_of_or_within GO:0006357 regulation of transcription by RNA polymerase II PMID:11904304 enables GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11904304 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0005634 nucleus PR:000026033 hMYC/iso:1/Ac:1 Lys-143/Lys-157/Lys-275/Lys-317/Lys-323/Lys-371, MOD:00394 PMID:16126174 PR:000026055 hMYC/iso:1/Phos:3 Ser-62/Ser-71, MOD:00046 PMID:12676581

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