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Protein Ontology Report - hCTNNB1

PR:P35222 - http://purl.obolibrary.org/obo/PR_P35222
This page represents a class of proteins encompassing all the protein products of the CTNNB1 gene in Homo sapiens.
Ontology Information
PRO ID PR:P35222 Show OBO stanza / PAF / GPI
PRO name catenin beta-1 (human)
Synonyms
PRO-short-label: EXACT: hCTNNB1
Gene-based: RELATED: CTNNB | CTNNB1 | OK/SW-cl.35 | PRO2286
Other: EXACT: beta-catenin (human)
Definition A catenin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P35222]
PRO Category organism-gene
Parent PR:000002198 catenin beta-1
Gene Template HGNC:2514 CTNNB1
Taxon NCBITaxon:9606 Homo sapiens
Terms by PRO Category Retrieve All terms OBO Stanza / PAF
Organism-Specific
Category Number of Terms
organism-gene 1
organism-sequence 1
organism-modification 25
Term Hierarchy Visualization DAG     OLS     Cytoscape


Interactive Sequence View Select/align proteoforms across species

Protein Forms
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation
PRO Term GO Annotation Evidence
PR:000037515
hCTNNB1/iso:1/Phos:11
Ser-33/Ser-37, MOD:00046 		acts_upstream_of_or_within GO:0060070 canonical Wnt signaling pathway decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
acts_upstream_of_or_within GO:0008283 cell population proliferation decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
enables GO:0005515 protein binding increased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 with PR:Q9Y297 hBTRC PMID:16996060, PMID:21152425, PMID:23071615
enables GO:0003713 transcription coactivator activity decreased relative to PR:000037772 hCTNNB1/iso:1/UnPhos:4 PMID:20307497
PR:000044510
hCTNNB1/iso:1/Phos:14
Ser-552, MOD:00046 		enables GO:0071889 14-3-3 protein binding with PR:P63104 hYWHAZ PMID:17287208
PR:000035772
hCTNNB1/iso:1/Phos:3
Ser-33/Ser-37/Ser-45, MOD:00046|Thr-41, MOD:00047 		enables GO:0005515 protein binding with PR:Q9Y297 hBTRC PMID:10074433
enables NOT GO:0005515 protein binding with PR:Q9UKB1 hFBXW11 PMID:10074433
PR:000037181
hCTNNB1/iso:1/Phos:6
Ser-37, MOD:00046|Thr-41, MOD:00047 		located_in GO:0005912 adherens junction decreased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:19667122
PR:000037192
hCTNNB1/iso:1/Phos:8
Tyr-333, MOD:00048 		acts_upstream_of_or_within GO:0007173 epidermal growth factor receptor signaling pathway PMID:22056988
enables GO:0005515 protein binding with PR:P14618 hPKM PMID:22056988
enables GO:0003713 transcription coactivator activity PMID:22056988
located_in GO:0005634 nucleus PMID:22056988
PR:000030192
hCTNNB1/iso:1/Phos:1
Ser-663/Ser-675, MOD:00046 		acts_upstream_of_or_within GO:0016055 Wnt signaling pathway PMID:22369945
enables GO:0003713 transcription coactivator activity increased relative to PR:000002862 CTNNB1/iso:1/UnMod PMID:22369945
PR:000037194
hCTNNB1/iso:1/Phos:9
Tyr-86/Tyr-654, MOD:00048 		enables GO:0045296 cadherin binding decreased relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 with PR:P12830 hCDH1 PMID:11279024
enables GO:0017025 TBP-class protein binding increased relative to PR:000037196 hCTNNB1/iso:1/UnPhos:3 with PR:P20226 hTBP PMID:11279024
PR:000035774
hCTNNB1/iso:1/Phos:4
Ser-45, MOD:00046 		enables GO:0005515 protein binding increased relative to PR:000037813 hCTNNB1/iso:1/UnPhos:6 with PR:P49841 hGSK3B PMID:12051714, PMID:20419129, PMID:23606879
enables GO:0005515 protein binding with PR:P12830 hCDH1 PMID:20419129, PMID:21152425
located_in GO:0005634 nucleus PMID:20419129
PR:000036862
hCTNNB1/iso:1/Phos:5
Ser-552/Ser-675, MOD:00046 		enables GO:0003713 transcription coactivator activity increased relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 PMID:16476742
enables GO:0005515 protein binding increased relative to PR:000036872 hCTNNB1/iso:1/UnPhos:1 with PR:Q92793 hCREBBP PMID:16476742
PR:000037185
hCTNNB1/iso:1/UnPhos:2
Ser-37/Thr-41, PR:000026291 		enables GO:0005515 protein binding with PR:P12830 hCDH1 PMID:20419129
enables GO:0003713 transcription coactivator activity PMID:20419129
located_in GO:0005634 nucleus PMID:20419129
PR:000044476
hCTNNB1/iso:1/UnPhos:7
Thr-393, PR:000026291 		enables GO:0005515 protein binding with PR:Q9YGY0 frog-axin PMID:19565571
PR:000044478
hCTNNB1/iso:1/Phos:13
Tyr-654, MOD:00048 		enables GO:0003713 transcription coactivator activity PMID:23640056
PR:000037190
hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047 		acts_upstream_of_or_within GO:0007155 cell adhesion decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
acts_upstream_of_or_within GO:0010631 epithelial cell migration PMID:21152425
acts_upstream_of_or_within GO:0034333 adherens junction assembly decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
enables GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:P36402 hTCF7 PMID:23617586
enables GO:0005515 protein binding increased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9Y297 hBTRC PMID:21152425
enables NOT GO:0005515 protein binding with PR:P12830 hCDH1 PMID:21152425
enables GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9HCS4 hTCF7L1 PMID:23617586
enables GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9NQB0 hTCF7L2 PMID:23617586
enables GO:0005515 protein binding decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 with PR:Q9UJU2 hLEF1 PMID:23617586
enables GO:0003713 transcription coactivator activity decreased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 PMID:20419129
located_in GO:0005912 adherens junction decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 PMID:19667122
located_in GO:0005737 cytoplasm PMID:20419129
PR:000035770
hCTNNB1/iso:1/Phos:2
located_in GO:0005634 nucleus PMID:20026641
PR:000044474
hCTNNB1/iso:1/Phos:12
Thr-393, MOD:00047 		acts_upstream_of_or_within GO:0016055 Wnt signaling pathway PMID:12700239
acts_upstream_of_or_within GO:0045944 positive regulation of transcription by RNA polymerase II PMID:12700239
enables GO:0005515 protein binding decreased relative to PR:000044476 hCTNNB1/iso:1/UnPhos:7 with PR:Q9YGY0 frog-axin PMID:19565571
Cellular Location GO Term Protein Forms & Complexes Evidence
GO:0005634 nucleus PR:000035770 hCTNNB1/iso:1/Phos:2

PMID:20026641
PR:000035774 hCTNNB1/iso:1/Phos:4
Ser-45, MOD:00046
PMID:20419129
PR:000037185 hCTNNB1/iso:1/UnPhos:2
Ser-37/Thr-41, PR:000026291
PMID:20419129
PR:000037192 hCTNNB1/iso:1/Phos:8
Tyr-333, MOD:00048
PMID:22056988
GO:0005737 cytoplasm PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
PMID:20419129
GO:0005912 adherens junction PR:000037181 hCTNNB1/iso:1/Phos:6
Ser-37, MOD:00046|Thr-41, MOD:00047
decreased relative to PR:000037185 hCTNNB1/iso:1/UnPhos:2 		PMID:19667122
PR:000037190 hCTNNB1/iso:1/Phos:7
Ser-33/Ser-37, MOD:00046|Thr-41, MOD:00047
decreased relative to PR:000037811 hCTNNB1/iso:1/UnPhos:5 		PMID:19667122

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