Protein Ontology Report - hCUL1 PR:Q13616 - http://purl.obolibrary.org/obo/PR_Q13616

This page represents a class of proteins encompassing all the protein products of the CUL1 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q13616 Show OBO stanza / PAF / GPI
PRO name	cullin-1 (human)
Synonyms	PRO-short-label: EXACT: hCUL1 Gene-based: RELATED: CUL1 Other: EXACT: CUL-1 (human)
Definition	A fungal/metazoan cullin-1 that is encoded in the genome of human. [PRO:DNx]
PRO Category	organism-gene
Parent	PR:000000092 fungal/metazoan cullin-1
Gene Template	HGNC:2551 CUL1
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 1 organism-modification 1
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	Reactome:R-HSA-174230, Reactome:R-HSA-187551, UniProtKB:Q13616

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

hCUL1 forms found in complexes
hCUL1 Component Complexes PR:Q13616 hCUL1 PR:000026772 SCF(Skp2) complex (human) PR:Q13616 hCUL1 PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human) PR:Q13616 hCUL1 PR:000026771 SCF beta-TrCP complex (human)

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000000092 CUL1 acts_upstream_of_or_within GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PANTHER:PTHR11932:SF19 part_of GO:0019005 SCF ubiquitin ligase complex PANTHER:PTHR11932:SF19 PR:000036454 hCUL1/iso:1/Nedd:1 Lys-720, MOD:01150 acts_upstream_of_or_within GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process PMID:10713156, PMID:10921923 acts_upstream_of_or_within GO:0097193 intrinsic apoptotic signaling pathway PMID:8681378 acts_upstream_of_or_within GO:0051726 regulation of cell cycle PMID:8681378 acts_upstream_of_or_within GO:0008285 negative regulation of cell population proliferation PMID:8681378 part_of GO:0019005 SCF ubiquitin ligase complex PMID:10713156, PMID:10921923, PMID:17098746 PR:Q13616-1 hCUL1/iso:1 enables GO:0005515 protein binding with PR:P62877-1 hRBX1/iso:1 PMID:12504026, PMID:15537541 enables GO:0005515 protein binding with PR:Q86VP6-1 hCAND1/iso:1 PMID:12504026, PMID:15537541 part_of NOT GO:0019005 SCF ubiquitin ligase complex PMID:10713156, PMID:10921923, PMID:12504026

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