Protein Ontology Report - hBMPR2 PR:Q13873 - http://purl.obolibrary.org/obo/PR_Q13873

This page represents a class of proteins encompassing all the protein products of the BMPR2 gene in Homo sapiens.

Ontology Information
PRO ID	PR:Q13873 Show OBO stanza / PAF / GPI
PRO name	bone morphogenetic protein receptor type-2 (human)
Synonyms	PRO-short-label: EXACT: hBMPR2 Gene-based: RELATED: BMPR2 | PPH1 Other: EXACT: BMP type II receptor (human) | BMP type-2 receptor (human) | BMPR-2 (human) | BMPR-II (human) | bone morphogenetic protein receptor type II (human)
Definition	A BMP receptor type-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13873]
PRO Category	organism-gene
Parent	PR:000000037 BMP receptor type-2
Gene Template	HGNC:1078 BMPR2
Taxon	NCBITaxon:9606 Homo sapiens
Terms by PRO Category	Retrieve All terms OBO Stanza / PAF Organism-Specific Category Number of Terms organism-gene 1 organism-sequence 16 organism-modification 3
Term Hierarchy Visualization	DAG     OLS     Cytoscape

Related Cross References
DB identifiers	DTO:03100043, UniProtKB:Q13873

Interactive Sequence View Select/align proteoforms across species

Protein Forms Display Category: All All organism-gene organism-sequence organism-modification
PRO ID & Category Annotation Complex Name Short Label Definition & Comment

Functional Annotation PRO Centric View GO Centric View

PRO Term GO Annotation Evidence PR:000000154 hBMPR2/var:N519K Asn-519, CHEBI:29967 associated_with_disease_progression DOID:14557 primary pulmonary hypertension UniProtKB_VAR:VAR_013683 PR:000000155 hBMPR2/var:C117Y Cys-117, CHEBI:46858 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11015450 PR:000000149 hBMPR2/var:C60Y Cys-60, CHEBI:46858 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11015450 PR:000000037 BMPR2 acts_upstream_of_or_within GO:0030509 BMP signaling pathway PIRSF:PIRSF500434 PR:000000152 hBMPR2/var:R491W Arg-491, CHEBI:29954 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10903931 PR:000000153 hBMPR2/var:K512T Lys-512, CHEBI:30013 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378 PR:000000150 hBMPR2/var:D485G Asp-485, CHEBI:29947 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10973254 PR:000000151 hBMPR2/var:R491Q Arg-491, CHEBI:30011 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10903931 PR:000000156 hBMPR2/var:C118W Cys-118, CHEBI:29954 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10973254 PR:000000157 hBMPR2/var:C123R Cys-123, CHEBI:29952 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378 PR:000000161 hBMPR2/var:C420R Cys-420, CHEBI:29952 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378 PR:000000160 hBMPR2/var:C347Y Cys-347, CHEBI:46858 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:10973254 PR:Q13873-1 hBMPR2/iso:1 acts_upstream_of_or_within GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway PMID:7644468 enables GO:0005515 protein binding with PR:P18075 hBMP7 PMID:7791754 enables GO:0005515 protein binding with PR:P12643 hBMP2 PMID:7791754 located_in GO:0009986 cell surface PMID:10712517 located_in GO:0005886 plasma membrane PMID:7791754 part_of GO:0043235 receptor complex PMID:7791754 PR:000000158 hBMPR2/var:C123S Cys-123, CHEBI:29999 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378 PR:000000159 hBMPR2/var:E224D Glu-224, CHEBI:29958 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11115378 PR:000000162 hBMPR2/var:C483R Cys-483, CHEBI:29952 associated_with_disease_progression DOID:14557 primary pulmonary hypertension PMID:11015450, PMID:12358323 Cellular Location GO Term Protein Forms & Complexes Evidence GO:0009986 cell surface PR:Q13873-1 hBMPR2/iso:1 PMID:10712517 GO:0005886 plasma membrane PR:Q13873-1 hBMPR2/iso:1 PMID:7791754

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