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Protein Ontology report - Toll/interleukin-1 receptor domain-containing adapter protein (human)
PR:P58753 - http://purl.obolibrary.org/obo/PR_P58753
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:P58753   
  PRO nameToll/interleukin-1 receptor domain-containing adapter protein (human) 
  Synonyms
PRO-Short-label: EXACT:hTIRAP
Gene-based: RELATED:MAL | TIRAP
Other: EXACT:adaptor protein Wyatt (human) | MyD88 adapter-like protein (human) | MyD88-2 (human) | TIR domain-containing adapter protein (human)
  Definition"A Toll/interleukin-1 receptor domain-containing adapter protein that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-gene 
  ParentPR:000001751 Toll/interleukin-1 receptor domain-containing adapter protein
PR:000029067 Homo sapiens protein
  Gene TemplateHGNC:17192 TIRAP (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene0                                                  Organism-Gene 1                                        
         Sequence0                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P58753
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
organism-gene


PR:P58753 Toll/interleukin-1 receptor domain-containing adapter protein (human)
hTIRAP

Yes
organism-sequence


PR:P58753-1 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)
hTIRAP/iso:1

Yes
organism-modification


PR:000027214 Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 phosphorylated 1 (human)
hTIRAP/iso:1/Phos:1

Yes
organism-sequence


PR:P58753-2 Toll/interleukin-1 receptor domain-containing adapter protein isoform 2 (human)
hTIRAP/iso:2
Yes
organism-sequence


PR:P58753-3 Toll/interleukin-1 receptor domain-containing adapter protein isoform h3 (human)
hTIRAP/iso:h3

organism-modification


PR:000049460 Toll/interleukin-1 receptor domain-containing adapter protein phosphorylated 2 (human)
hTIRAP/Phos:2

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hTIRAP forms found in complexes   

hTIRAP Component
 Complexes
PR:000027214 hTIRAP/iso:1/Phos:1 PR:000027218 pTIRAP:PIP2:activated TLR4 complex (human)
PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:000037448 pTIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753 hTIRAP PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
PR:000036014 TIRAP:PIP2 complex (human)
PR:000037447 TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:P58753ZDASHZ1 hTIRAP/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000036135 TIRAP:PIP2:activated TLR4 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P58753-2 hTIRAP/iso:2 enablesGO:0005546 phosphatidylinositol-4,5-bisphosphate binding PMID:24529375