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Protein Ontology report - smad4
PR:000000128 - http://purl.obolibrary.org/obo/PR_000000128
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000128   
  PRO namesmad4 
  Synonyms
PRO-Short-label: EXACT:SMAD4
Gene-based: RELATED:DPC4 | MADH4
Other: EXACT:deletion target in pancreatic carcinoma 4 | deletion target in pancreatic carcinoma 4 homolog | MAD homolog 4 | mothers against DPP homolog 4 | SMAD 4 | SMAD family member 4
  Definition"A smad protein that is a translation product of the human SMAD4 gene or a 1:1 ortholog thereof. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation, that is present in the receptor-regulated smads." [PMID:10708949, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000027 smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 90                                        
         Modification5                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500408
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000128 smad4
SMAD4

organism-gene


PR:O70437 mothers against decapentaplegic homolog 4 (rat)
rSMAD4

organism-gene


PR:P97471 mothers against decapentaplegic homolog 4 (mouse)
mSMAD4

organism-sequence


PR:P97471-1 mothers against decapentaplegic homolog 4 isoform 1 (mouse)
mSMAD4/iso:1
Yes
Yes
organism-gene


PR:Q13485 mothers against decapentaplegic homolog 4 (human)
hSMAD4

Yes
organism-sequence


PR:000000367 smad4 sequence variant E330G (human)
hSMAD4/var:E330G
Yes
organism-sequence


PR:000000368 smad4 sequence variant G352R (human)
hSMAD4/var:G352R
Yes
organism-sequence


PR:000000369 smad4 sequence variant R361C (human)
hSMAD4/var:R361C
Yes
organism-sequence


PR:000000370 smad4 sequence variant G386D (human)
hSMAD4/var:G386D
Yes
organism-sequence


PR:000000371 smad4 sequence variant D493H (human)
hSMAD4/var:D493H
Yes
organism-sequence


PR:000060297 mothers against decapentaplegic homolog 4 sequence variant E538* (human)
hSMAD4/var:E538*

organism-sequence


PR:000060358 mothers against decapentaplegic homolog 4 sequence variant D351G (human)
hSMAD4/var:D351G

organism-sequence


PR:000060432 mothers against decapentaplegic homolog 4 sequence variant G30* (human)
hSMAD4/var:G30*

organism-sequence


PR:000060505 mothers against decapentaplegic homolog 4 sequence variant R445* (human)
hSMAD4/var:R445*

organism-sequence


PR:000060581 mothers against decapentaplegic homolog 4 sequence variant E390* (human)
hSMAD4/var:E390*

organism-sequence


PR:000060584 mothers against decapentaplegic homolog 4 sequence variant G358* (human)
hSMAD4/var:G358*

organism-sequence


PR:000060627 mothers against decapentaplegic homolog 4 sequence variant Q410* (human)
hSMAD4/var:Q410*

organism-sequence


PR:000060690 mothers against decapentaplegic homolog 4 sequence variant D351H (human)
hSMAD4/var:D351H

organism-sequence


PR:000060699 mothers against decapentaplegic homolog 4 sequence variant E526* (human)
hSMAD4/var:E526*

organism-sequence


PR:000060742 mothers against decapentaplegic homolog 4 sequence variant Q83* (human)
hSMAD4/var:Q83*

organism-sequence


PR:000060841 mothers against decapentaplegic homolog 4 sequence variant Y276* (human)
hSMAD4/var:Y276*

organism-sequence


PR:000060874 mothers against decapentaplegic homolog 4 sequence variant G473* (human)
hSMAD4/var:G473*

organism-sequence


PR:000060913 mothers against decapentaplegic homolog 4 sequence variant G477* (human)
hSMAD4/var:G477*

organism-sequence


PR:000060944 mothers against decapentaplegic homolog 4 sequence variant E49* (human)
hSMAD4/var:E49*

organism-sequence


PR:000060985 mothers against decapentaplegic homolog 4 sequence variant W398* (human)
hSMAD4/var:W398*

organism-sequence


PR:000060992 mothers against decapentaplegic homolog 4 sequence variant Q183* (human)
hSMAD4/var:Q183*

organism-sequence


PR:000061015 mothers against decapentaplegic homolog 4 sequence variant Y95* (human)
hSMAD4/var:Y95*

organism-sequence


PR:000061059 mothers against decapentaplegic homolog 4 sequence variant Q116* (human)
hSMAD4/var:Q116*

organism-sequence


PR:000061241 mothers against decapentaplegic homolog 4 sequence variant W302* (human)
hSMAD4/var:W302*

organism-sequence


PR:000061304 mothers against decapentaplegic homolog 4 sequence variant E330* (human)
hSMAD4/var:E330*

organism-sequence


PR:000061339 mothers against decapentaplegic homolog 4 sequence variant C443* (human)
hSMAD4/var:C443*

organism-sequence


PR:000061457 mothers against decapentaplegic homolog 4 sequence variant Q249* (human)
hSMAD4/var:Q249*

organism-sequence


PR:000061581 mothers against decapentaplegic homolog 4 sequence variant E108* (human)
hSMAD4/var:E108*

organism-sequence


PR:000061625 mothers against decapentaplegic homolog 4 sequence variant Y412* (human)
hSMAD4/var:Y412*

organism-sequence


PR:000061684 mothers against decapentaplegic homolog 4 sequence variant W524* (human)
hSMAD4/var:W524*

organism-sequence


PR:000061708 mothers against decapentaplegic homolog 4 sequence variant K428R (human)
hSMAD4/var:K428R

organism-sequence


PR:000061756 mothers against decapentaplegic homolog 4 sequence variant E175* (human)
hSMAD4/var:E175*

organism-sequence


PR:000061768 mothers against decapentaplegic homolog 4 sequence variant Q516* (human)
hSMAD4/var:Q516*

organism-sequence


PR:000061774 mothers against decapentaplegic homolog 4 sequence variant L440* (human)
hSMAD4/var:L440*

organism-sequence


PR:000061833 mothers against decapentaplegic homolog 4 sequence variant Q224* (human)
hSMAD4/var:Q224*

organism-sequence


PR:000061868 mothers against decapentaplegic homolog 4 sequence variant Q256* (human)
hSMAD4/var:Q256*

organism-sequence


PR:000061967 mothers against decapentaplegic homolog 4 sequence variant A406T (human)
hSMAD4/var:A406T

organism-sequence


PR:000061978 mothers against decapentaplegic homolog 4 sequence variant W268* (human)
hSMAD4/var:W268*

organism-sequence


PR:000062067 mothers against decapentaplegic homolog 4 sequence variant P356R (human)
hSMAD4/var:P356R

organism-sequence


PR:000062090 mothers against decapentaplegic homolog 4 sequence variant Q248* (human)
hSMAD4/var:Q248*

organism-sequence


PR:000062129 mothers against decapentaplegic homolog 4 sequence variant Y513* (human)
hSMAD4/var:Y513*

organism-sequence


PR:000062175 mothers against decapentaplegic homolog 4 sequence variant G510* (human)
hSMAD4/var:G510*

organism-sequence


PR:000062259 mothers against decapentaplegic homolog 4 sequence variant G352* (human)
hSMAD4/var:G352*

organism-sequence


PR:000062302 mothers against decapentaplegic homolog 4 sequence variant R361G (human)
hSMAD4/var:R361G

organism-sequence


PR:000062369 mothers against decapentaplegic homolog 4 sequence variant E307* (human)
hSMAD4/var:E307*

organism-sequence


PR:000062486 mothers against decapentaplegic homolog 4 sequence variant D351Y (human)
hSMAD4/var:D351Y

organism-sequence


PR:000062687 mothers against decapentaplegic homolog 4 sequence variant W509* (human)
hSMAD4/var:W509*

organism-sequence


PR:000062700 mothers against decapentaplegic homolog 4 sequence variant K428T (human)
hSMAD4/var:K428T

organism-sequence


PR:000062729 mothers against decapentaplegic homolog 4 sequence variant Q366* (human)
hSMAD4/var:Q366*

organism-sequence


PR:000062770 mothers against decapentaplegic homolog 4 sequence variant R361S (human)
hSMAD4/var:R361S

organism-sequence


PR:000062793 mothers against decapentaplegic homolog 4 sequence variant Y195* (human)
hSMAD4/var:Y195*

organism-sequence


PR:000062878 mothers against decapentaplegic homolog 4 sequence variant Y328* (human)
hSMAD4/var:Y328*

organism-sequence


PR:000062888 mothers against decapentaplegic homolog 4 sequence variant Q289* (human)
hSMAD4/var:Q289*

organism-sequence


PR:000062894 mothers against decapentaplegic homolog 4 sequence variant S154* (human)
hSMAD4/var:S154*

organism-sequence


PR:000062923 mothers against decapentaplegic homolog 4 sequence variant W101* (human)
hSMAD4/var:W101*

organism-sequence


PR:000062931 mothers against decapentaplegic homolog 4 sequence variant Q534* (human)
hSMAD4/var:Q534*

organism-sequence


PR:000062943 mothers against decapentaplegic homolog 4 sequence variant L146* (human)
hSMAD4/var:L146*

organism-sequence


PR:000062969 mothers against decapentaplegic homolog 4 sequence variant Q455* (human)
hSMAD4/var:Q455*

organism-sequence


PR:000063050 mothers against decapentaplegic homolog 4 sequence variant K122* (human)
hSMAD4/var:K122*

organism-sequence


PR:000063052 mothers against decapentaplegic homolog 4 sequence variant R515T (human)
hSMAD4/var:R515T

organism-sequence


PR:000063094 mothers against decapentaplegic homolog 4 sequence variant P356L (human)
hSMAD4/var:P356L

organism-sequence


PR:000063098 mothers against decapentaplegic homolog 4 sequence variant E417* (human)
hSMAD4/var:E417*

organism-sequence


PR:000063207 mothers against decapentaplegic homolog 4 sequence variant Q311* (human)
hSMAD4/var:Q311*

organism-sequence


PR:000063208 mothers against decapentaplegic homolog 4 sequence variant Y260* (human)
hSMAD4/var:Y260*

organism-sequence


PR:000063251 mothers against decapentaplegic homolog 4 sequence variant Q239* (human)
hSMAD4/var:Q239*

organism-sequence


PR:000063265 mothers against decapentaplegic homolog 4 sequence variant S242* (human)
hSMAD4/var:S242*

organism-sequence


PR:000063355 mothers against decapentaplegic homolog 4 sequence variant S138* (human)
hSMAD4/var:S138*

organism-sequence


PR:000063397 mothers against decapentaplegic homolog 4 sequence variant Q442* (human)
hSMAD4/var:Q442*

organism-sequence


PR:000063419 mothers against decapentaplegic homolog 4 sequence variant R515* (human)
hSMAD4/var:R515*

organism-sequence


PR:000063609 mothers against decapentaplegic homolog 4 sequence variant G168* (human)
hSMAD4/var:G168*

organism-sequence


PR:000063714 mothers against decapentaplegic homolog 4 sequence variant E520* (human)
hSMAD4/var:E520*

organism-sequence


PR:000063741 mothers against decapentaplegic homolog 4 sequence variant E205* (human)
hSMAD4/var:E205*

organism-sequence


PR:000063751 mothers against decapentaplegic homolog 4 sequence variant E53* (human)
hSMAD4/var:E53*

organism-sequence


PR:000063757 mothers against decapentaplegic homolog 4 sequence variant R135* (human)
hSMAD4/var:R135*

organism-sequence


PR:000063792 mothers against decapentaplegic homolog 4 sequence variant Q334* (human)
hSMAD4/var:Q334*

organism-sequence


PR:000063853 mothers against decapentaplegic homolog 4 sequence variant Y322* (human)
hSMAD4/var:Y322*

organism-sequence


PR:000063915 mothers against decapentaplegic homolog 4 sequence variant Q245* (human)
hSMAD4/var:Q245*

organism-sequence


PR:000063918 mothers against decapentaplegic homolog 4 sequence variant S144* (human)
hSMAD4/var:S144*

organism-sequence


PR:000064002 mothers against decapentaplegic homolog 4 sequence variant Q250* (human)
hSMAD4/var:Q250*

organism-sequence


PR:000064188 mothers against decapentaplegic homolog 4 sequence variant S178* (human)
hSMAD4/var:S178*

organism-sequence


PR:000064193 mothers against decapentaplegic homolog 4 sequence variant E33* (human)
hSMAD4/var:E33*

organism-sequence


PR:000064298 mothers against decapentaplegic homolog 4 sequence variant S171* (human)
hSMAD4/var:S171*

organism-sequence


PR:000064338 mothers against decapentaplegic homolog 4 sequence variant Y430* (human)
hSMAD4/var:Y430*

organism-sequence


PR:000064356 mothers against decapentaplegic homolog 4 sequence variant S343* (human)
hSMAD4/var:S343*

organism-sequence


PR:000064413 mothers against decapentaplegic homolog 4 sequence variant Q448* (human)
hSMAD4/var:Q448*

organism-sequence


PR:000064414 mothers against decapentaplegic homolog 4 sequence variant L172* (human)
hSMAD4/var:L172*

organism-sequence


PR:000064437 mothers against decapentaplegic homolog 4 sequence variant E321* (human)
hSMAD4/var:E321*

organism-sequence


PR:000064488 mothers against decapentaplegic homolog 4 sequence variant R361H (human)
hSMAD4/var:R361H

organism-sequence


PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human)
hSMAD4/iso:1
Yes
Yes
organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)
hSMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
hSMAD4/iso:1/MonoUbiq:2
Yes
organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)
hSMAD4/iso:1/Phos:1
Yes
organism-modification


PR:000045915 mothers against decapentaplegic homolog 4 phosphorylated 1 (human)
hSMAD4/Phos:1

organism-modification


PR:000049288 mothers against decapentaplegic homolog 4 ADP-ribosylated form (human)
hSMAD4/ADPribRes+

organism-modification


PR:000064798 mothers against decapentaplegic homolog 4 ubiquitinated form (human)
hSMAD4/UbiqLys+

organism-modification


PR:000067581 mothers against decapentaplegic homolog 4 methylated 1 (human)
hSMAD4/Me:1

organism-modification


PR:000074844 mothers against decapentaplegic homolog 4 methylated 2 (human)
hSMAD4/Me:2

organism-modification


PR:000075597 mothers against decapentaplegic homolog 4 deaminated 1 (human)
hSMAD4/Deam:1

organism-modification


PR:000083975 mothers against decapentaplegic homolog 4 methylated 3 (human)
hSMAD4/Me:3

sequence


PR:000000366 smad4 isoform 1
SMAD4/iso:1

Yes
organism-sequence


PR:P97471-1 mothers against decapentaplegic homolog 4 isoform 1 (mouse)
mSMAD4/iso:1
Yes
Yes
organism-sequence


PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human)
hSMAD4/iso:1
Yes
Yes
organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)
hSMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
hSMAD4/iso:1/MonoUbiq:2
Yes
organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)
hSMAD4/iso:1/Phos:1
Yes
modification


PR:000000476 smad4 isoform 1 phosphorylated form
SMAD4/iso:1/PhosRes+

modification


PR:000000579 smad4 isoform 1 phosphorylated 1
SMAD4/iso:1/Phos:1

organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)
hSMAD4/iso:1/Phos:1
Yes
modification


PR:000002539 smad4 isoform 1 unmodified form
SMAD4/iso:1/UnMod

modification


PR:000025955 smad4 isoform 1 monoubiquitinated 1
SMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)
hSMAD4/iso:1/MonoUbiq:1

modification


PR:000025957 smad4 isoform 1 monoubiquitinated 2
SMAD4/iso:1/MonoUbiq:2

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
hSMAD4/iso:1/MonoUbiq:2
Yes
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SMAD4 forms found in complexes   

SMAD4 Component
 Complexes
PR:000000366 SMAD4/iso:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025968 smad2-smad4 protein complex 2
PR:000025969 smad2-smad4 protein complex 3
PR:000025970 smad2-smad4 protein complex 4
PR:000025971 smad2-smad4-ski protein complex 1
PR:000025972 smad2-smad4-ski protein complex 2
PR:P97471ZDASHZ1 mSMAD4/iso:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:Q13485 hSMAD4 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:Q13485ZDASHZ1 hSMAD4/iso:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025952 smad2-smad4-ski protein complex 2 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000367 hSMAD4/var:E330G
UniProtKB:Q13485, Glu-330, CHEBI:29947		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000368 hSMAD4/var:G352R
UniProtKB:Q13485, Gly-352, CHEBI:29952		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
DO:4905 pancreatic carcinoma PMID:12417513
PR:000000369 hSMAD4/var:R361C
UniProtKB:Q13485, Arg-361, CHEBI:29950		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:9811934
PR:000000370 hSMAD4/var:G386D
UniProtKB:Q13485, Gly-386, CHEBI:29958		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:15031030
PR:000000371 hSMAD4/var:D493H
UniProtKB:Q13485, Asp-493, CHEBI:29979		 associated_with_disease_progressionDO:4905 pancreatic carcinoma PMID:8553070
PR:000025958 hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148		 acts_upstream_of_or_withinGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PMID:19135894
enablesNOT GO:0046332 SMAD binding PMID:19135894
PR:000036483 hSMAD4/iso:1/Phos:1
UniProtKB:Q13485-1, Thr-277, MOD:00047		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12801888
enablesincreased GO:0003700 DNA-binding transcription factor activity relative to PR:000002539 SMAD4/iso:1/UnMod PMID:12801888
located_inGO:0005634 nucleus PMID:12801888
PR:P97471-1 mSMAD4/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805
GO:0030509 BMP signaling pathway PMID:16522160
enablesGO:0003700 DNA-binding transcription factor activity PMID:12943993; PMID:14633973; PMID:16522160; PMID:16556916
located_inGO:0005634 nucleus PMID:12543979; PMID:12943993; PMID:16522160
GO:0005667 transcription factor complex PMID:14633973; PMID:9288972; PMID:9702197
PR:Q13485-1 hSMAD4/iso:1 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17142805; PMID:8774881
GO:0030509 BMP signaling pathway PMID:14633973
GO:0060395 SMAD protein signal transduction PMID:10980615; PMID:15350224; PMID:9346966
enablesGO:0003700 DNA-binding transcription factor activity PMID:10823886
GO:0003712 transcription coregulator activity PMID:10980615
located_inGO:0005634 nucleus PMID:10980615; PMID:15280432
GO:0005667 transcription factor complex PMID:12374795
GO:0005737 cytoplasm PMID:15280432