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RACE-PRO
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Protein Ontology report - smad4 isoform 1
PR:000000366 -
http://purl.obolibrary.org/obo/PR_000000366
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000366
PRO name
smad4 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
SMAD4/iso:1
Definition
"A smad4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:Q13485-1
or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
PRO Category
sequence
Parent
PR:000000128
smad4
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
2
Modification
5
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000000366
smad4 isoform 1, SMAD4/iso:1
Yes
organism-sequence
PR:P97471-1
mothers against decapentaplegic homolog 4 isoform 1 (mouse), mSMAD4/iso:1
Yes
Yes
organism-sequence
PR:Q13485-1
mothers against decapentaplegic homolog 4 isoform 1 (human), hSMAD4/iso:1
Yes
Yes
organism-modification
PR:000025956
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1
organism-modification
PR:000025958
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2
Yes
organism-modification
PR:000036483
mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1
Yes
modification
PR:000000476
smad4 isoform 1 phosphorylated form, SMAD4/iso:1/PhosRes+
modification
PR:000000579
smad4 isoform 1 phosphorylated 1, SMAD4/iso:1/Phos:1
organism-modification
PR:000036483
mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human), hSMAD4/iso:1/Phos:1
Yes
modification
PR:000002539
smad4 isoform 1 unmodified form, SMAD4/iso:1/UnMod
modification
PR:000025955
smad4 isoform 1 monoubiquitinated 1, SMAD4/iso:1/MonoUbiq:1
organism-modification
PR:000025956
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human), hSMAD4/iso:1/MonoUbiq:1
modification
PR:000025957
smad4 isoform 1 monoubiquitinated 2, SMAD4/iso:1/MonoUbiq:2
organism-modification
PR:000025958
mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human), hSMAD4/iso:1/MonoUbiq:2
Yes
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SMAD4/iso:1
forms found in complexes
SMAD4/iso:1
Component
Complexes
PR:000000366
SMAD4/iso:1
PR:000025967
smad2-smad4 protein complex 1
PR:000025968
smad2-smad4 protein complex 2
PR:000025969
smad2-smad4 protein complex 3
PR:000025970
smad2-smad4 protein complex 4
PR:000025971
smad2-smad4-ski protein complex 1
PR:000025972
smad2-smad4-ski protein complex 2
PR:P97471ZDASHZ1
mSMAD4/iso:1
PR:000025944
smad2-smad4 protein complex 1 (mouse)
PR:000025945
smad2-smad4 protein complex 2 (mouse)
PR:Q13485ZDASHZ1
hSMAD4/iso:1
PR:000025940
smad2-smad4 protein complex 2 (human)
PR:000025946
smad2-smad4 protein complex 3 (human)
PR:000025947
smad2-smad4 protein complex 4 (human)
PR:000025951
smad2-smad4-ski protein complex 1 (human)
PR:000025952
smad2-smad4-ski protein complex 2 (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025958
hSMAD4/iso:1/MonoUbiq:2
UniProtKB:Q13485-1, Lys-519, MOD:01148
"A smad4 isoform 1 monoubiquitinated 2 in human. UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:19135894]
acts_upstream_of_or_within
GO:0030512
negative regulation of transforming growth factor beta receptor signaling pathway
PMID:19135894
enables
NOT
GO:0046332
SMAD binding
PMID:19135894
PR:000036483
hSMAD4/iso:1/Phos:1
UniProtKB:Q13485-1, Thr-277, MOD:00047
"A smad4 isoform 1 phosphorylated 1 in human. UniProtKB:Q13485-1, Thr-277, MOD:00047." [PMID:12801888, PRO:CNA]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:12801888
enables
increased
GO:0003700
DNA-binding transcription factor activity
relative to
PR:000002539
SMAD4/iso:1/UnMod
PMID:12801888
located_in
GO:0005634
nucleus
PMID:12801888
PR:P97471-1
mSMAD4/iso:1
"A smad4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:17142805
GO:0030509
BMP signaling pathway
PMID:16522160
enables
GO:0003700
DNA-binding transcription factor activity
PMID:12943993
;
PMID:14633973
;
PMID:16522160
;
PMID:16556916
located_in
GO:0005634
nucleus
PMID:12543979
;
PMID:12943993
;
PMID:16522160
GO:0005667
transcription factor complex
PMID:14633973
;
PMID:9288972
;
PMID:9702197
PR:Q13485-1
hSMAD4/iso:1
"A smad4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:17142805
;
PMID:8774881
GO:0030509
BMP signaling pathway
PMID:14633973
GO:0060395
SMAD protein signal transduction
PMID:10980615
;
PMID:15350224
;
PMID:9346966
enables
GO:0003700
DNA-binding transcription factor activity
PMID:10823886
GO:0003712
transcription coregulator activity
PMID:10980615
located_in
GO:0005634
nucleus
PMID:10980615
;
PMID:15280432
GO:0005667
transcription factor complex
PMID:12374795
GO:0005737
cytoplasm
PMID:15280432