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Protein Ontology report - smad4 isoform 1
PR:000000366 - http://purl.obolibrary.org/obo/PR_000000366
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000366   
  PRO namesmad4 isoform 1 
  Synonyms
PRO-Short-label: EXACT:SMAD4/iso:1
  Definition"A smad4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13485-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000128 smad4
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000366 smad4 isoform 1
SMAD4/iso:1

Yes
organism-sequence


PR:P97471-1 mothers against decapentaplegic homolog 4 isoform 1 (mouse)
mSMAD4/iso:1
Yes
Yes
organism-sequence


PR:Q13485-1 mothers against decapentaplegic homolog 4 isoform 1 (human)
hSMAD4/iso:1
Yes
Yes
organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)
hSMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
hSMAD4/iso:1/MonoUbiq:2
Yes
organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)
hSMAD4/iso:1/Phos:1
Yes
modification


PR:000000476 smad4 isoform 1 phosphorylated form
SMAD4/iso:1/PhosRes+

modification


PR:000000579 smad4 isoform 1 phosphorylated 1
SMAD4/iso:1/Phos:1

organism-modification


PR:000036483 mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human)
hSMAD4/iso:1/Phos:1
Yes
modification


PR:000002539 smad4 isoform 1 unmodified form
SMAD4/iso:1/UnMod

modification


PR:000025955 smad4 isoform 1 monoubiquitinated 1
SMAD4/iso:1/MonoUbiq:1

organism-modification


PR:000025956 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human)
hSMAD4/iso:1/MonoUbiq:1

modification


PR:000025957 smad4 isoform 1 monoubiquitinated 2
SMAD4/iso:1/MonoUbiq:2

organism-modification


PR:000025958 mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human)
hSMAD4/iso:1/MonoUbiq:2
Yes
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SMAD4/iso:1 forms found in complexes   

SMAD4/iso:1 Component
 Complexes
PR:000000366 SMAD4/iso:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025968 smad2-smad4 protein complex 2
PR:000025969 smad2-smad4 protein complex 3
PR:000025970 smad2-smad4 protein complex 4
PR:000025971 smad2-smad4-ski protein complex 1
PR:000025972 smad2-smad4-ski protein complex 2
PR:P97471ZDASHZ1 mSMAD4/iso:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000025945 smad2-smad4 protein complex 2 (mouse)
PR:Q13485ZDASHZ1 hSMAD4/iso:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025952 smad2-smad4-ski protein complex 2 (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000036483 hSMAD4/iso:1/Phos:1 PMID:12801888
PR:P97471-1 mSMAD4/iso:1 PMID:17142805
PR:Q13485-1 hSMAD4/iso:1 PMID:17142805; PMID:8774881
GO:0030509 BMP signaling pathwayPR:P97471-1 mSMAD4/iso:1 PMID:16522160
PR:Q13485-1 hSMAD4/iso:1 PMID:14633973
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathwayPR:000025958 hSMAD4/iso:1/MonoUbiq:2 PMID:19135894
GO:0060395 SMAD protein signal transductionPR:Q13485-1 hSMAD4/iso:1 PMID:10980615; PMID:15350224; PMID:9346966

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0003700 DNA-binding transcription factor activityPR:000036483 hSMAD4/iso:1/Phos:1 PMID:12801888
PR:P97471-1 mSMAD4/iso:1 PMID:12943993; PMID:14633973; PMID:16522160; PMID:16556916
PR:Q13485-1 hSMAD4/iso:1 PMID:10823886
GO:0003712 transcription coregulator activityPR:Q13485-1 hSMAD4/iso:1 PMID:10980615
NOT GO:0046332 SMAD bindingPR:000025958 hSMAD4/iso:1/MonoUbiq:2 PMID:19135894

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000036483 hSMAD4/iso:1/Phos:1 PMID:12801888
PR:P97471-1 mSMAD4/iso:1 PMID:12543979; PMID:12943993; PMID:16522160
PR:Q13485-1 hSMAD4/iso:1 PMID:10980615; PMID:15280432
GO:0005667 transcription factor complexPR:P97471-1 mSMAD4/iso:1 PMID:14633973; PMID:9288972; PMID:9702197
PR:Q13485-1 hSMAD4/iso:1 PMID:12374795
GO:0005737 cytoplasmPR:Q13485-1 hSMAD4/iso:1 PMID:15280432