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Protein Ontology report - TGF-beta 1 isoform 1
PR:000000397 -
http://purl.obolibrary.org/obo/PR_000000397
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000397
PRO name
TGF-beta 1 isoform 1
Synonyms
PRO-Short-label
:
EXACT:
TGFB1/iso:1
Definition
"A TGF-beta 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by
UniProtKB:P01137-1
or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
PRO Category
sequence
Parent
PR:000000182
TGF-beta 1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
1
Organism-Sequence
3
Modification
5
Organism-Modification
8
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
sequence
PR:000000397
TGF-beta 1 isoform 1
TGFB1/iso:1
"A TGF-beta 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01137-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
organism-sequence
PR:P01137-1
transforming growth factor beta-1 isoform 1 (human)
hTGFB1/iso:1
"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]
Yes
Yes
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]
Yes
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P04202-1
transforming growth factor beta-1 isoform 1 (mouse)
mTGFB1/iso:1
"A TGF-beta 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P09533-1
transforming growth factor beta-1 isoform 1 (green monkey)
GrMonkey-TGFB1/iso:1
"A TGF-beta 1 isoform 1 that is encoded in the genome of green monkey." [PRO:DAN]
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]
Yes
modification
PR:000000616
TGF-beta 1 isoform 1 mature form
TGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example: UniProtKB:P01137-1, 279-390." [PMID:3162913, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000025927
TGF-beta 1 isoform 1 mature form (human)
hTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]
Yes
Yes
organism-modification
PR:000025928
TGF-beta 1 isoform 1 mature form (mouse)
mTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468]
Yes
organism-modification
PR:000025929
TGF-beta 1 isoform 1 mature form (rat)
rTGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552]
Yes
Yes
organism-modification
PR:000025930
TGF-beta 1 isoform 1 mature form (green monkey)
GrMonkey-TGFB1/iso:1/mature
"A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545]
Yes
modification
PR:000002555
TGF-beta 1 isoform 1 unmodified form
TGFB1/iso:1/UnMod
"A TGF-beta 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
modification
PR:000025454
TGF-beta 1 isoform 1, signal peptide removed form
TGFB1/iso:1/SigPep-
"A TGF-beta 1 isoform 1 that has had the signal peptide removed." [PRO:DAN]
modification
PR:000000617
TGF-beta 1 isoform 1 latency associated peptide
TGFB1/iso:1/LAP
"A TGF-beta 1 isoform 1, signal peptide removed form that has had the C-terminal mature peptide removed and has been N-glycosylated mainly at either one of the two first consensus N-glycosylation sites. Example: UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:3162913, PRO:CNA, PRO:DAN]
organism-modification
PR:000036526
TGF-beta 1 isoform 1 latency associated peptide (human)
hTGFB1/iso:1/LAP
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]
Yes
modification
PR:000000618
TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:3162913, PMID:3185545, PRO:CNA, PRO:DAN]
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
"A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN]
Yes
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TGFB1/iso:1
forms found in complexes
TGFB1/iso:1
Component
Complexes
PR:000000616
TGFB1/iso:1/mature
PR:000025925
dimeric TGF-beta 1
PR:000025927
hTGFB1/iso:1/mature
PR:000025926
dimeric TGF-beta 1 (human)
PR:000025929
rTGFB1/iso:1/mature
PR:000025931
dimeric TGF-beta 1 (rat)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000025927
hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:8471846
GO:0043066
negative regulation of apoptotic process
PMID:9918798
enables
GO:0042803
protein homodimerization activity
PMID:3162913
;
PMID:8471846
located_in
GO:0031012
extracellular matrix
PMID:8294500
PR:000025928
mTGFB1/iso:1/mature
UniProtKB:P04202-1, 279-390
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
enables
GO:0005160
transforming growth factor beta receptor binding
PMID:14764882
located_in
GO:0031012
extracellular matrix
PMID:9008713
PR:000025929
rTGFB1/iso:1/mature
UniProtKB:P17246-1, 279-390
located_in
GO:0031012
extracellular matrix
PMID:11907708
PR:000025930
GrMonkey-TGFB1/iso:1/mature
UniProtKB:P09533-1, 279-390
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3185545
enables
GO:0042803
protein homodimerization activity
PMID:3185545
located_in
GO:0031012
extracellular matrix
PMID:3185545
PR:000026335
hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:3162913
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:2677679
;
PMID:3162913
GO:0042803
protein homodimerization activity
PMID:3162913
located_in
GO:0031012
extracellular matrix
PMID:17015622
;
PMID:8294500
GO:0032991
protein-containing complex
PMID:3162913
PR:000036526
hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160
located_in
GO:0032991
protein-containing complex
PMID:17015622
;
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:1448117
;
PMID:2677679
enables
NOT
GO:0005160
transforming growth factor beta receptor binding
PMID:1448117
located_in
GO:0032991
protein-containing complex
PMID:1448117
;
PMID:2677679
PR:000036529
mTGFB1/iso:1/inactive
UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
located_in
GO:0031012
extracellular matrix
PMID:9008713
PR:P01137-1
hTGFB1/iso:1
acts_upstream_of_or_within
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:1544940
GO:0043066
negative regulation of apoptotic process
PMID:9918798
enables
GO:0042803
protein homodimerization activity
PMID:1544940
located_in
GO:0005796
Golgi lumen
PMID:1544940
PR:P04202-1
mTGFB1/iso:1
acts_upstream_of_or_within
GO:0030879
mammary gland development
PMID:1821856
