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Protein Ontology report - transforming growth factor beta-1 isoform 1 (human)
PR:P01137-1 - http://purl.obolibrary.org/obo/PR_P01137-1
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF / GPI
  PRO ID
PR:P01137-1   
  PRO nametransforming growth factor beta-1 isoform 1 (human) 
  Synonyms
PRO-Short-label: EXACT:hTGFB1/iso:1
  Definition"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA] 
  PRO Categoryorganism-sequence 
  ParentPR:000000397 TGF-beta 1 isoform 1
PR:P01137 transforming growth factor beta-1 (human)
  TaxonNCBITaxon:9606 Homo sapiens
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence0                                                  Organism-Sequence 1                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
UniProtKB:P01137-1
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Ann. Has Annotation?

Comp. In Complex?
organism-sequence


PR:P01137-1 transforming growth factor beta-1 isoform 1 (human), hTGFB1/iso:1
Yes
organism-modification


PR:000025927 TGF-beta 1 isoform 1 mature form (human), hTGFB1/iso:1/mature
Yes
Yes
organism-modification


PR:000026335 TGF-beta 1 isoform 1 inactive form (human), hTGFB1/iso:1/inactive
Yes
organism-modification


PR:000036526 TGF-beta 1 isoform 1 latency associated peptide (human), hTGFB1/iso:1/LAP
Yes
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hTGFB1/iso:1 forms found in complexes   

hTGFB1/iso:1 Component
 Complexes
PR:000025927 hTGFB1/iso:1/mature PR:000025926 dimeric TGF-beta 1 (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025927 hTGFB1/iso:1/mature
UniProtKB:P01137-1, 279-390 | PRO_0000033763
"A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8471846
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:3162913; PMID:8471846
located_inGO:0031012 extracellular matrix PMID:8294500
PR:000026335 hTGFB1/iso:1/inactive
UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160 | PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
enablesNOT GO:0005160 transforming growth factor beta receptor binding PMID:2677679; PMID:3162913
GO:0042803 protein homodimerization activity PMID:3162913
located_inGO:0031012 extracellular matrix PMID:17015622; PMID:8294500
GO:0032991 protein-containing complex PMID:3162913
PR:000036526 hTGFB1/iso:1/LAP
UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160
"A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN]		 located_inGO:0032991 protein-containing complex PMID:17015622; PMID:3162913
PR:P01137-1 hTGFB1/iso:1

"A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:1544940
GO:0043066 negative regulation of apoptotic process PMID:9918798
enablesGO:0042803 protein homodimerization activity PMID:1544940
located_inGO:0005796 Golgi lumen PMID:1544940