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Protein Ontology report - smad2 isoform Short
PR:000000469 - http://purl.obolibrary.org/obo/PR_000000469
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000469   
  PRO namesmad2 isoform Short 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Short
Other: EXACT:mothers against decapentaplegic homolog 2 isoform 2 | smad2 isoform 2
RELATED:exon3delta | short isoform
  Definition"A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-2 or a 1:1 ortholog thereof." [PMID:8752209, PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000364 smad2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000469 smad2 isoform Short
SMAD2/iso:Short

organism-sequence


PR:Q15796-2 mothers against decapentaplegic homolog 2 isoform Short (human)
hSMAD2/iso:Short

organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
organism-modification


PR:000045494 smad2 isoform Short unphosphorylated 1 (human)
hSMAD2/iso:Short/UnPhos:1

organism-sequence


PR:Q62432-2 mothers against decapentaplegic homolog 2 isoform Short (mouse)
mSMAD2/iso:Short

organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000576 smad2 isoform Short phosphorylated form
SMAD2/iso:Short/PhosRes+

modification


PR:000000575 smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+

modification


PR:000000655 smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1

organism-modification


PR:000036556 smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
Yes
modification


PR:000000656 smad2 isoform Short phosphorylated 1
SMAD2/iso:Short/Phos:1

Yes
organism-modification


PR:000025938 smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
Yes
Yes
organism-modification


PR:000025943 smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
Yes
Yes
modification


PR:000002571 smad2 isoform Short unmodified form
SMAD2/iso:Short/UnMod

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SMAD2/iso:Short forms found in complexes   

SMAD2/iso:Short Component
 Complexes
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025938 hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
enablesGO:0003677 DNA binding PMID:14701940; PMID:9873005
GO:0003700 DNA-binding transcription factor activity PMID:9873005
GO:0003712 transcription coregulator activity PMID:14701940; PMID:9873005
PR:000025943 mSMAD2/iso:Short/Phos:1
UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:15630024
enablesGO:0003700 DNA-binding transcription factor activity PMID:15630024
PR:000036556 hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003677 DNA binding PMID:17074756
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756