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Protein Ontology report - smad2 isoform Short
PR:000000469 - http://purl.obolibrary.org/obo/PR_000000469
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000469   
  PRO namesmad2 isoform Short 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Short
Other: EXACT:mothers against decapentaplegic homolog 2 isoform 2 | smad2 isoform 2
RELATED:exon3delta | short isoform
  Definition"A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-2 or a 1:1 ortholog thereof." [PMID:8752209, PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000364 smad2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000469

smad2 isoform Short

SMAD2/iso:Short


"A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-2 or a 1:1 ortholog thereof." [PMID:8752209, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q15796-2

mothers against decapentaplegic homolog 2 isoform Short (human)

hSMAD2/iso:Short


"A smad2 isoform Short that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15796]


organism-modification



PR:000025938

smad2 isoform Short phosphorylated 1 (human)

hSMAD2/iso:Short/Phos:1


"A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]

Yes

Yes
organism-modification



PR:000036556

smad2 isoform Short acetylated and phosphorylated 1 (human)

hSMAD2/iso:Short/AcPhos:1


"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

organism-modification



PR:000045494

smad2 isoform Short unphosphorylated 1 (human)

hSMAD2/iso:Short/UnPhos:1


"A mothers against decapentaplegic homolog 2 isoform Short (human) that lacks phosphorylation on the last two Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, PR:000026291." [PRO:CNA]


organism-sequence



PR:Q62432-2

mothers against decapentaplegic homolog 2 isoform Short (mouse)

mSMAD2/iso:Short


"A smad2 isoform Short that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q62432]


organism-modification



PR:000025943

smad2 isoform Short phosphorylated 1 (mouse)

mSMAD2/iso:Short/Phos:1


"A smad2 isoform Short phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]

Yes

Yes
modification



PR:000000575

smad2 isoform Short acetylated and phosphorylated form

SMAD2/iso:Short/AcPhos+


"A smad2 isoform Short that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000655

smad2 isoform Short acetylated and phosphorylated 1

SMAD2/iso:Short/AcPhos:1


"A smad2 isoform Short acetylated and phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation and acetylated in a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756]


organism-modification



PR:000036556

smad2 isoform Short acetylated and phosphorylated 1 (human)

hSMAD2/iso:Short/AcPhos:1


"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

modification



PR:000000576

smad2 isoform Short phosphorylated form

SMAD2/iso:Short/PhosRes+


"A smad2 isoform Short that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000575

smad2 isoform Short acetylated and phosphorylated form

SMAD2/iso:Short/AcPhos+


"A smad2 isoform Short that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000655

smad2 isoform Short acetylated and phosphorylated 1

SMAD2/iso:Short/AcPhos:1


"A smad2 isoform Short acetylated and phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation and acetylated in a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756]


organism-modification



PR:000036556

smad2 isoform Short acetylated and phosphorylated 1 (human)

hSMAD2/iso:Short/AcPhos:1


"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]

Yes

modification



PR:000000656

smad2 isoform Short phosphorylated 1

SMAD2/iso:Short/Phos:1


"A smad2 isoform Short phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PMID:15630024, PMID:17074756, PMID:9873005]


Yes
organism-modification



PR:000025938

smad2 isoform Short phosphorylated 1 (human)

hSMAD2/iso:Short/Phos:1


"A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]

Yes

Yes
organism-modification



PR:000025943

smad2 isoform Short phosphorylated 1 (mouse)

mSMAD2/iso:Short/Phos:1


"A smad2 isoform Short phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]

Yes

Yes
modification



PR:000002571

smad2 isoform Short unmodified form

SMAD2/iso:Short/UnMod


"A smad2 isoform Short that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


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SMAD2/iso:Short forms found in complexes   

SMAD2/iso:Short Component
Complexes
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:9873005
PR:000025943 mSMAD2/iso:Short/Phos:1 PMID:15630024
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0003677 DNA bindingPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:14701940; PMID:9873005
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
GO:0003700 DNA-binding transcription factor activityPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:9873005
PR:000025943 mSMAD2/iso:Short/Phos:1 PMID:15630024
PR:000036556 hSMAD2/iso:Short/AcPhos:1 PMID:17074756
GO:0003712 transcription coregulator activityPR:000025938 hSMAD2/iso:Short/Phos:1 PMID:14701940; PMID:9873005