back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - myeloid differentiation primary response protein MyD88
PR:000001740 - http://purl.obolibrary.org/obo/PR_000001740
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000001740   
  PRO namemyeloid differentiation primary response protein MyD88 
  Synonyms
PRO-Short-label: EXACT:MYD88
  Definition"A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response." [PMID:9575168, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 11                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF037756
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000001740

myeloid differentiation primary response protein MyD88

MYD88


"A protein that is a translation product of the human MYD88 gene or a 1:1 ortholog thereof. This protein is an adapter involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response." [PMID:9575168, PRO:CNA]


Yes
organism-gene



PR:A5HNF6

myeloid differentiation primary response protein MyD88 (chicken)

chick-MYD88


"A myeloid differentiation primary response protein MyD88 that is encoded in the genome of chicken." [OMA:A5HNF6, PMID:18582498, PRO:CNA]


Yes
organism-gene



PR:P22366

myeloid differentiation primary response protein MyD88 (mouse)

mMYD88


"A myeloid differentiation primary response protein MyD88 that is encoded in the genome of mouse." [OMA:P22366, PRO:CNA]


organism-sequence



PR:P22366-1

myeloid differentiation primary response protein MyD88 isoform 1 (mouse)

mMYD88/iso:1


"A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]


Yes
organism-sequence



PR:P22366-2

myeloid differentiation primary response protein MyD88 isoform 2 (mouse)

mMYD88/iso:2


"A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]

Yes

Yes
organism-gene



PR:Q5XJ85

myeloid differentiation primary response protein MyD88 (zebrafish)

z-MYD88


"A myeloid differentiation primary response protein MyD88 that is encoded in the genome of zebrafish." [OMA:Q5XJ85, PRO:DNx]


organism-gene



PR:Q6Y1S1

myeloid differentiation primary response protein MyD88 (rat)

rMYD88


"A myeloid differentiation primary response protein MyD88 that is encoded in the genome of rat." [OMA:Q6Y1S1, PRO:DNx]


organism-gene



PR:Q7K105

LD20892p (fruit fly)

fly-MYD88


"A myeloid differentiation primary response protein MyD88 that is encoded in the genome of fruit fly." [PANTHER:PTHR15079:SF0, PRO:DNx]


organism-gene



PR:Q99836

myeloid differentiation primary response protein MyD88 (human)

hMYD88


"A myeloid differentiation primary response protein MyD88 that is encoded in the genome of human." [PRO:CNA]


Yes
organism-sequence



PR:000001742

myeloid differentiation primary response protein MyD88 sequence variant L93P (human)

hMYD88/var:L93P


"A myeloid differentiation primary response protein MyD88 (human) that has a Pro residue at the position equivalent to Leu-93 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Leu-93, CHEBI:50342." [PMID:18669862, PRO:CNA, PRO:DAN]


organism-sequence



PR:000001743

myeloid differentiation primary response protein MyD88 sequence variant R196C (human)

hMYD88/var:R196C


"A myeloid differentiation primary response protein MyD88 (human) that has a Cys residue at the position equivalent to Arg-196 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Arg-196, CHEBI:29950." [PMID:18669862, PRO:CNA, PRO:DAN]


organism-sequence



PR:000061325

myeloid differentiation primary response protein MyD88 sequence variant S34Y (human)

hMYD88/var:S34Y


"A myeloid differentiation primary response protein MyD88 (human) that has a Tyr residue at the position equivalent to Ser-34 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Ser-34, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-5602521]


organism-sequence



PR:Q99836-1

myeloid differentiation primary response protein MyD88 isoform 1 (human)

hMYD88/iso:1


"A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human." [PRO:CNA]


Yes
organism-sequence



PR:Q99836-2

myeloid differentiation primary response protein MyD88 isoform 2 (human)

hMYD88/iso:2


"A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q99836-3

myeloid differentiation primary response protein MyD88 isoform h3 (human)

hMYD88/iso:h3


"A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-3." [PRO:DNx, UniProtKB:Q99836]


organism-sequence



PR:Q99836-4

myeloid differentiation primary response protein MyD88 isoform h4 (human)

hMYD88/iso:h4


"A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-4." [PRO:DNx, UniProtKB:Q99836]


organism-sequence



PR:Q99836-5

myeloid differentiation primary response protein MyD88 isoform h5 (human)

hMYD88/iso:h5


"A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-5." [PRO:DNx, UniProtKB:Q99836]


organism-sequence



PR:Q99836-6

myeloid differentiation primary response protein MyD88 isoform h6 (human)

hMYD88/iso:h6


"A myeloid differentiation primary response protein MyD88 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-6." [PRO:DNx, UniProtKB:Q99836]


organism-modification



PR:000065926

myeloid differentiation primary response protein MyD88 methylated 1 (human)

hMYD88/Me:1


"A myeloid differentiation primary response protein MyD88 (human) that has been methylated on the residue at the position equivalent to Cys-233 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Cys-233, MOD:00660." [IEDB_epitope:1023386, PRO:DNx]


organism-modification



PR:000078147

myeloid differentiation primary response protein MyD88 cysteinylated 1 (human)

hMYD88/Cyst:1


"A myeloid differentiation primary response protein MyD88 (human) that has been cysteinylated on the residue at the position equivalent to Cys-280 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Cys-280, MOD:00765." [IEDB_epitope:933188, PRO:DNx]


organism-modification



PR:000082882

myeloid differentiation primary response protein MyD88 cysteinylated 2 (human)

hMYD88/Cyst:2


"A myeloid differentiation primary response protein MyD88 (human) that has been cysteinylated on the residue at the position equivalent to Cys-203 of the amino acid sequence represented by UniProtKB:Q99836-1. Example: UniProtKB:Q99836-1, Cys-203, MOD:00765." [IEDB_epitope:1331425, PRO:DNx]


sequence



PR:000001741

myeloid differentiation primary response protein MyD88 isoform 1

MYD88/iso:1


"A myeloid differentiation primary response protein MyD88 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99836-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P22366-1

myeloid differentiation primary response protein MyD88 isoform 1 (mouse)

mMYD88/iso:1


"A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]


Yes
organism-sequence



PR:Q99836-1

myeloid differentiation primary response protein MyD88 isoform 1 (human)

hMYD88/iso:1


"A myeloid differentiation primary response protein MyD88 isoform 1 that is encoded in the genome of human." [PRO:CNA]


Yes
sequence



PR:000024846

myeloid differentiation primary response protein MyD88 isoform 2

MYD88/iso:2


"A myeloid differentiation primary response protein MyD88 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22366-2 or a 1:1 ortholog thereof." [PMID:11909531, PRO:CNA, PRO:DAN]


organism-sequence



PR:P22366-2

myeloid differentiation primary response protein MyD88 isoform 2 (mouse)

mMYD88/iso:2


"A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of mouse." [PMID:11909531, PRO:CNA]

Yes

Yes
organism-sequence



PR:Q99836-2

myeloid differentiation primary response protein MyD88 isoform 2 (human)

hMYD88/iso:2


"A myeloid differentiation primary response protein MyD88 isoform 2 that is encoded in the genome of human." [PRO:CNA]


Back to top
MYD88 forms found in complexes   

MYD88 Component
Complexes
PR:000001740 MYD88 PR:000025784 MYD88:TIRAP:activated TLR4 receptor
PR:000027182 IRAK4:MYD88:TIRAP:activated TLR4 complex
PR:A5HNF6 chick-MYD88 PR:000037475 MYD88:TIRAP:activated TLR4 receptor (chicken)
PR:P22366ZDASHZ1 mMYD88/iso:1 PR:000027175 MYD88l:TIRAP:activated TLR4 receptor (mouse)
PR:000027187 IRAK4:MYD88:TIRAP:activated TLR4 complex (mouse)
PR:000027220 IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027221 pIRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000027267 IRAK3:IRAK1:IRAK4:MYD88:TIRAP:activated TLR4 (mouse)
PR:000037481 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
PR:P22366ZDASHZ2 mMYD88/iso:2 PR:000027174 MYD88s:TIRAP:activated TLR4 receptor (mouse)
PR:Q99836 hMYD88 PR:000037446 MYD88:TIRAP:PIP2:BTK:activated TLR4 complex (human)
PR:Q99836ZDASHZ1 hMYD88/iso:1 PR:000027183 IRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027192 pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
PR:000027495 pIRAK1:pIRAK4:MYD88:TIRAP:activated TLR4 (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P22366-2 mMYD88/iso:2 acts_upstream_of_or_withinGO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway PMID:12538665