back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - TNF receptor-associated factor 6
PR:000002292 - http://purl.obolibrary.org/obo/PR_000002292
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000002292   
  PRO nameTNF receptor-associated factor 6 
  Synonyms
PRO-Short-label: EXACT:TRAF6
Gene-based: RELATED:RNF85
Other: EXACT:E3 ubiquitin-protein ligase TRAF6 | interleukin-1 signal transducer | RING finger protein 85 | RING-type E3 ubiquitin transferase TRAF6
  Definition"A TNF receptor-associated factor that is a translation product of the human TRAF6 gene or a 1:1 ortholog thereof." [PRO:WCB] 
  PRO Categorygene 
  ParentPR:000002191 TNF receptor-associated factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000002292 TNF receptor-associated factor 6
TRAF6

organism-gene


PR:B5DF45 TNF receptor-associated factor 6 (rat)
rTRAF6

organism-gene


PR:P70196 TNF receptor-associated factor 6 (mouse)
mTRAF6

Yes
organism-sequence


PR:P70196-1 TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1

organism-sequence


PR:P70196-2 TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2

organism-gene


PR:Q6IWL4 TNF receptor-associated factor 6 (zebrafish)
z-TRAF6

organism-gene


PR:Q9Y4K3 TNF receptor-associated factor 6 (human)
hTRAF6

Yes
organism-sequence


PR:Q9Y4K3-1 TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1

organism-modification


PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
Yes
Yes
organism-modification


PR:000064696 TNF receptor-associated factor 6 ubiquitinated form (human)
hTRAF6/UbiqLys+

organism-modification


PR:000066371 TNF receptor-associated factor 6 cysteinylated 1 (human)
hTRAF6/Cyst:1

sequence


PR:000002381 TNF receptor-associated factor 6 isoform 1
TRAF6/iso:1

organism-sequence


PR:P70196-1 TNF receptor-associated factor 6 isoform 1 (mouse)
mTRAF6/iso:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1

organism-sequence


PR:Q9Y4K3-1 TNF receptor-associated factor 6 isoform 1 (human)
hTRAF6/iso:1

modification


PR:000003138 TNF receptor-associated factor 6 isoform 1 ubiquitinated form
TRAF6/iso:1/UbiqLys+

modification


PR:000003139 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1
TRAF6/iso:1/K63polyUbiq:1

organism-modification


PR:000035712 TNF receptor-associated factor 6 isoform 1 K63-polyubiquitinated 1 (mouse)
mTRAF6/iso:1/K63polyUbiq:1

sequence


PR:000002382 TNF receptor-associated factor 6 isoform 2
TRAF6/iso:2

organism-sequence


PR:P70196-2 TNF receptor-associated factor 6 isoform 2 (mouse)
mTRAF6/iso:2

modification


PR:000035713 TNF receptor-associated factor 6 K63-polyubiquitinated 1
TRAF6/K63polyUbiq:1

organism-modification


PR:000035714 TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
hTRAF6/K63polyUbiq:1
Yes
Yes
Back to top
TRAF6 forms found in complexes   

TRAF6 Component
 Complexes
PR:000035714 hTRAF6/K63polyUbiq:1 PR:000035715 pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035740 free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037338 free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340 pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342 free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:P70196 mTRAF6 PR:000035710 traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036101 rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036105 pel1:rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036109 pel1:K63-poly-Ub-rip1:traf6:ticam1:ticam2:activated TLR4 complex (mouse)
PR:000036111 K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036114 IkappaB kinase:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000036117 pIKBK:K63-poly-Ub-rip1:traf6:TAK1 kinase complex (mouse)
PR:000037471 traf6:ticam1:activated TLR3 complex (mouse)
PR:Q9Y4K3 hTRAF6 PR:000028680 traf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000037344 traf6:ticam1:activated TLR3 complex (human)
Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000035714 hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772		 acts_upstream_of_or_withinGO:0034142 toll-like receptor 4 signaling pathway Reactome:REACT_6894