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Documentation
Protein Ontology report - TNF receptor-associated factor 6 K63-polyubiquitinated 1
PR:000035713 -
http://purl.obolibrary.org/obo/PR_000035713
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000035713
PRO name
TNF receptor-associated factor 6 K63-polyubiquitinated 1
Synonyms
PRO-Short-label
:
EXACT:
TRAF6/K63polyUbiq:1
Definition
"A TNF receptor-associated factor 6 that is a major product of site-specific Lys-63-linked auto-ubiquitination. Example:
UniProtKB:Q9Y4K3
, Lys-124,
PR:000044772
." [PRO:CNx, PRO:DAN]
Comment
Requested by=TLR.
PRO Category
modification
Parent
PR:000002292
TNF receptor-associated factor 6
PR:000037077
ubiquitinated protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
1
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
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Extended View
Category
PRO Form Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000035713
TNF receptor-associated factor 6 K63-polyubiquitinated 1, TRAF6/K63polyUbiq:1
organism-modification
PR:000035714
TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human), hTRAF6/K63polyUbiq:1
Yes
Yes
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TRAF6/K63polyUbiq:1
forms found in complexes
TRAF6/K63polyUbiq:1
Component
Complexes
PR:000035714
hTRAF6/K63polyUbiq:1
PR:000035715
pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035734
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035738
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
PR:000035740
free K63-linked pUb:activated TAK1 complex:pUbtraf6 complex (human)
PR:000037338
free K63-linked pUb:activated TAK1 complex:pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037340
pUbtraf6:ticam1:activated TLR3 complex (human)
PR:000037342
free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:activated TLR3 complex (human)
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Functional Annotation (PRO-centric view)
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GO Centric View
PRO Term
GO Annotation
Evidence
PR:000035714
hTRAF6/K63polyUbiq:1
UniProtKB:Q9Y4K3, Lys-124, PR:000044772 | K63-pUb-TRAF6
"A TNF receptor-associated factor 6 K63-polyubiquitinated 1 in human. UniProtKB:Q9Y4K3, Lys-124, PR:000044772." [PRO:DAN, UniProtKB:Q9Y4K3]
acts_upstream_of_or_within
GO:0034142
toll-like receptor 4 signaling pathway
Reactome:REACT_6894
